Continuous Rapid Quantification of Stroke Volume Using Magnetohydrodynamic Voltages in 3T Magnetic Resonance Imaging.
Continuous Rapid Quantification of Stroke Volume Using Magnetohydrodynamic Voltages in 3T Magnetic Resonance Imaging.
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DOI：
10.1161/circimaging.115.003282
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Ho Tse ZT
中科院分区：
文献类型：
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作者：
Gregory TS;Oshinski J;Schmidt EJ;Kwong RY;Stevenson WG;Ho Tse ZT
开发一种技术，根据 MRI 检查期间心电图 (ECG) 记录中出现的感应磁流体动力电压 (VMHD)，在磁共振成像 (MRI) 引导程序期间实时非侵入性地估计每搏输出量 (SV)，从而使 MRI 扫描仪可以自由执行其他成像任务。由于血流 (BF) 和 VMHD 之间的关系，我们假设可以从心向量图参考框架 (VMHDVCG) 中提取的 VMHD 向量导出获得 SV 的方法。为了评估受试者特定的 BF-VMHD 模型，在 10 名受试者 (n=10) 和一名诊断为室性早搏 (PVC) 的受试者中，在 20 秒屏气期间获取 VMHDVCG，并与使用相差磁共振 (PCMR) 测量的主动脉 BF 进行校准。使用实时相位对比 (RTPC) 成像对 7 名健康受试者 (n=7) 在 15 分钟心脏运动压力测试期间和 3T MRI 压力松弛后 30 分钟进行逐次心跳验证 VMHDVCG 衍生的 BF。导出特定于受试者的方程，将 VMHDVCG 与静息时的 BF 相关联，并使用 RTPC 进行验证。在峰值应力期间和完全松弛后，SV 估计的平均误差分别为 7.22% 和 3.69%。使用斯皮尔曼等级相关系数在压力测试期间 (0.89) 和压力松弛后 (=0.86)，从 RTPC 和 VMHD 得出的测量的逐搏血流时程高度相关。使用从 MRI 内 12 导联心电图提取的 VMHDVCG 来估计准确的逐搏 SV 和 BF，从而提供了一种在 MR 成像和 MR 引导干预期间增强患者监测的方法。
To develop a technique to non-invasively estimate Stroke Volume (SV) in real-time during Magnetic Resonance Imaging (MRI) guided procedures, based on induced Magnetohydrodynamic Voltages (VMHD) that occur in Electrocardiogram (ECG) recordings during MRI exams, leaving the MRI scanner free to perform other imaging tasks. Due to the relationship between blood-flow (BF) and VMHD, we hypothesized that a method to obtain SV could be derived from extracted VMHD vectors in the Vectorcardiogram frame-of-reference (VMHDVCG). To estimate a subject-specific BF-VMHD model, VMHDVCG was acquired during a 20-second breath-hold and calibrated versus aortic BF measured using Phase Contrast Magnetic Resonance (PCMR) in 10 subjects (n=10) and one subject diagnosed with Premature Ventricular Contractions (PVCs). Beat-to-Beat validation of VMHDVCG derived BF was performed using Real-Time Phase Contrast (RTPC) imaging in 7 healthy subjects (n=7) during a 15 minute cardiac exercise stress tests and 30 minutes after stress relaxation in 3T MRIs. Subject-specific equations were derived to correlate VMHDVCG to BF at rest, and validated using RTPC. An average error of 7.22% and 3.69% in SV estimation, respectively, was found during peak stress, and after complete relaxation. Measured beat-to-beat blood flow time-history derived from RTPC and VMHD were highly correlated using a Spearman Rank Correlation Coefficient during stress tests (0.89) and after stress relaxation (=0.86). Accurate beat-to-beat SV and BF were estimated using VMHDVCG extracted from intra-MRI 12-lead ECGs, providing a means to enhance patient monitoring during MR imaging and MR-guided interventions.