Dendritic cells maximize the memory CD8 T cell response to infection
Dendritic cells maximize the memory CD8 T cell response to infection
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DOI：
10.1016/j.immuni.2005.03.005
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发表时间：
2005-05-01
期刊：
影响因子：
32.4
通讯作者：
Lefrançois, L
中科院分区：
文献类型：
--
作者：
Zammit, DJ;Cauley, LS;Lefrançois, L
幼稚 T 细胞需要来自树突状细胞 (DC) 的共刺激信号才能对抗原刺激做出反应。 DC 在回忆反应期间重新激活记忆 T 细胞的程度尚不清楚。在这里，体内耗竭系统被用来分析 DC 在对三种不同微生物感染的回忆反应期间重新激活 CD8 记忆 T 细胞的作用。我们发现，在对水泡性口炎病毒、单核细胞增生李斯特菌 (Lm) 或流感病毒感染的回忆反应期间，淋巴组织和非淋巴组织中的反应性记忆 CD8 T 细胞数量显着减少。这些数据表明，即使在呼吸道组织特异性感染期间，与 DC 的相互作用也是驱动体内 T 细胞重新激活的主要机制。
Costimulatory signals from dendritic cells (DCs) are required for naive T cells to respond to antigenic stimulation. To what extent DCs reactivate memory T cells during recall responses is not known. Here, an in vivo depletion system has been used to analyze the role of DCs in reactivating CD8 memory T cells during recall responses to three different microbial infections. We show a profound decrease in the numbers of responding memory CD8 T cells in both lymphoid and nonlymphoid tissues during the recall responses to infection with vesicular stomatitis virus, Listeria monocytogenes (Lm), or influenza virus. These data show that interaction with DCs is a major mechanism driving T cell reactivation in vivo, even during a tissue-specific infection of the respiratory tract.