Moving towards personalised therapy in head and neck squamous cell carcinoma through analysis of next generation sequencing data.
Moving towards personalised therapy in head and neck squamous cell carcinoma through analysis of next generation sequencing data.
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DOI：
10.1016/j.ejca.2015.10.070
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发表时间：
2016-03
期刊：
影响因子：
--
通讯作者：
Ferlito A
中科院分区：
文献类型：
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作者：
Giefing M;Wierzbicka M;Szyfter K;Brenner JC;Braakhuis BJ;Brakenhoff RH;Bradford CR;Sorensen JA;Rinaldo A;Rodrigo JP;Takes RP;Ferlito A
利用基因组数据改善临床管理的个性化医学肿瘤委员会正在成为许多癌症治疗的标准。本文旨在作为一个引物，以帮助临床医生治疗头颈部鳞状细胞癌（HNSCC）患者的复发性遗传病变的发现和功能的影响，可能会影响这种疾病的管理在不久的将来的理解。这份手稿整合了来自公开的aCGH和NGS遗传学数据库的遗传数据，以确定HNSCC中最常见的分子改变。这些遗传发现的重要性进行审查，并讨论如何将其纳入临床护理决策。遗传分层在头颈癌临床管理中的作用的考虑正在迅速成熟，并可以通过整合数据集来改善。本文旨在总结使用多个基因组平台的发现，以便头颈癌护理提供者可以应用这些发现来改善临床护理。
Personalized medicine tumor boards, which leverage genomic data to improve clinical management, are becoming standard for the treatment of many cancers. This paper is designed as a primer to assist clinicians treating head and neck squamous cell carcinoma (HNSCC) patients with an understanding of the discovery and functional impact of recurrent genetic lesions that are likely to influence the management of this disease in the near future. This manuscript integrates genetic data from publicly available aCGH and NGS genetics databases to identify the most common molecular alterations in HNSCC. The importance of these genetic discoveries is reviewed and how they may be incorporated into clinical care decisions is discussed. Considerations for the role of genetic stratification in the clinical management of head and neck cancer are maturing rapidly and can be improved by integrating data sets. This article is meant to summarize the discoveries made using multiple genomic platforms so that the head and neck cancer care provider can apply these discoveries to improve clinical care.