Clinicostatistical analyses of medication‐related osteonecrosis of the jaws (MRONJ): Evaluation of the treatment method and prognosis
Clinicostatistical analyses of medication‐related osteonecrosis of the jaws (MRONJ): Evaluation of the treatment method and prognosis
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药物相关性颌骨坏死（MRONJ）的临床统计分析：治疗方法和预后评估
DOI：
10.1002/osi2.1098
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发表时间：
2020
影响因子：
0.5
通讯作者：
Kaneko Akihiro
中科院分区：
文献类型：
--
作者：
Osaka Ryuta;Kato Hiroshi;Hamada Yuji;Fujimoto Yasuhiro;Mizusawa Nobuhito;Watanabe Daisuke;Kaneko Akihiro
目的：药物相关性颌骨骨坏死（MRONJ）是一种与使用抗吸收药物如双膦酸盐（BP）和地诺单抗（Dmab）相关的不良事件。MRONJ的主要临床症状为进行性颌骨破坏、持续疼痛、骨外露、软组织肿胀、瘘管和感染。这些症状影响患者的生活质量。然而，对于MRONJ的适当治疗方法尚无共识。本研究旨在探讨MRONJ患者的治疗方法及预后。方法对88例MRONJ患者进行回顾性分析。检查和分析各种人口统计学和治疗相关变量，以确定其与预后的相关性。结果慢剂量抗吸收药物加手术治疗效果较好。此外，在55例接受手术治疗的患者中，接受广泛手术的患者预后明显优于保守手术的患者。结论本研究结果支持日本立场文件提出的“II至III期疾病推荐手术治疗”的主张。然而，手术治疗的选择标准和手术方法可能因机构而异。今后有必要开展多中心的研究，探讨手术治疗的标准。
ObjectiveMedication‐related osteonecrosis of the jaw (MRONJ) is an adverse event associated with the use of antiresorptive agents such as bisphosphonate (BP) and denosumab (Dmab). The major clinical symptoms of MRONJ are progressive destruction of the jaw, prolonged pain, bone exposure, soft tissue swelling, fistula, and infections. These symptoms influence the patients’ quality of life. However, there is no consensus on the appropriate treatment approach for MRONJ. This retrospective study aimed to investigate the treatment methods and prognosis in patients with MRONJ.MethodsA total of 88 MRONJ patients were retrospectively examined. Various demographic and treatment‐related variables were examined and analyzed to determine their correlations with the prognoses.ResultsLow‐dose administration of an antiresorptive agent and surgical treatment showed better outcomes. Furthermore, among 55 patients who underwent surgical treatment, those who underwent extensive surgery experienced significantly better prognosis than those who underwent conservative surgery.ConclusionThe results of this study support the assertion that "surgical therapy is recommended for stage II to III disease" as proposed by Japanese position paper. However, the selection criteria for surgical treatment and the method of surgery may vary from one institution to another.In future, it is necessary to conduct a multi‐center research and examine the criteria for surgical treatment.
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影响因子：
0.5
作者：
Suzuki, Taiki;Sekiya, Ryo;Sakamoto, Haruo
通讯作者：
Sakamoto, Haruo
日式沙拉——沙拉纸
DOI：
--
发表时间：
2011
期刊：
影响因子：
--
作者：
Oho;Atsushi;Masahiro Yamada
通讯作者：
Masahiro Yamada
影响因子：
1.8
作者：
Blus, Cornelio;Giannelli, Giulio;Orru, Germano
通讯作者：
Orru, Germano
双膦酸盐相关的颌骨坏死：立场文件
影响因子：
3.3
作者：
Saiwichai T;Sangalangkarn V;Kawahara K;Oyama Y;Chaichalotornkul S;Narkpinit S;Harnyuttanakorn P;Singhasivanon P;Maruyama I;Tancharoen S;Komada Yukiya;Amizuka N;Yoneda T
通讯作者：
Yoneda T
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影响因子：
2.9
作者：
C. Jacobsen;P. Metzler;J. Obwegeser;W. Zemann;K. Graetz
通讯作者：
K. Graetz