Wnt signaling in vertebrate neural development and function.

Wnt signaling in vertebrate neural development and function.
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脊椎动物神经发育和功能中的Wnt信号传导。

DOI:
10.1007/s11481-012-9404-x
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发表时间:
2012-12
影响因子:
6.2
通讯作者:
Cheyette, Benjamin N. R.
Cheyette, Benjamin N. R.
中科院分区:
医学3区
文献类型:
--
作者:
Mulligan, Kimberly A.;Cheyette, Benjamin N. R.

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分泌信号蛋白的Wnt家族成员影响神经发育和功能的许多方面。从神经诱导和轴形成到轴突引导和突触发育都需要wnt,甚至帮助调节突触活动。Wnt蛋白激活多种下游信号通路,并可诱导类似的多种细胞反应,包括基因转录变化和细胞骨架重排。本文就Wnt信号通路及其在脊椎动物神经发育和功能中的作用作一综述。
Members of the Wnt family of secreted signaling proteins influence many aspects of neural development and function. Wnts are required from neural induction and axis formation to axon guidance and synapse development, and even help modulate synapse activity. Wnt proteins activate a variety of downstream signaling pathways and can induce a similar variety of cellular responses, including gene transcription changes and cytoskeletal rearrangements. This review provides an introduction to Wnt signaling pathways and discusses current research on their roles in vertebrate neural development and function.
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