Associations between water iodine concentration and the prevalence of dyslipidemia in Chinese adults: A cross-sectional study
Associations between water iodine concentration and the prevalence of dyslipidemia in Chinese adults: A cross-sectional study
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水碘浓度与中国成人血脂异常患病率的关联：一项横断面研究
DOI：
10.1016/j.ecoenv.2020.111682
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发表时间：
2021
影响因子：
6.8
通讯作者：
Liu Lixiang
中科院分区：
文献类型：
--
作者：
Wang D;an;Wan Siyuan;Liu Peng;Meng Fangang;Ren Bingxuan;Qu Mengying;Wu Huaiyong;Zhou Zheng;Jin Meihui;Shen Hongmei;Liu Lixiang
碘对甲状腺功能和脂质代谢都很重要。一些研究探讨了甲状腺激素（TH）和尿碘浓度（UIC）对血脂水平的影响。然而，碘摄入量和血脂异常之间的关系尚未得到很好的确定。本研究旨在探讨水碘浓度（WIC）与血脂异常（包括高胆固醇血症、高甘油三酯血症、低高密度脂蛋白胆固醇（HDL-C）和高低密度脂蛋白胆固醇（LDL-C））的关系。对来自碘缺乏（中位数水碘，MWI < 10 µg/L）、碘充足（MWI在40和100 µg/L之间）和碘过量（MWI > 100 µ g/L）地区的409、390和436名成年人（≥18岁）进行了横断面调查。测定WIC、总胆固醇（TC）、甘油三酯（TRIG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）。根据WIC水平，采用卡方检验法计算血脂异常的患病率。为了进一步探讨患病率是否与WIC相关，采用简单线性回归和多元Logistic回归模型。与WIC为40-100 µg/L的受试者相比，WIC>100 µg/L可预防高胆固醇血症[校正比值比（AOR）= 0.649，95%置信区间（CI）：0.455-0.924]和低HDL-C（AOR = 0.429，95% CI：0.264-0.697）的发生。研究发现，高甘油三酯血症、低HDL-C和高LDL-C的患病率与WIC呈倒U型相关，WIC为40-100 µg/L时达到顶点。总的来说，我们的研究表明血清脂质水平与WIC相关。在碘过量（>100 µg/L）的情况下，WIC和血脂异常之间的获益效应相关性出现。
Iodine is important in both thyroid function and lipid metabolism. Some studies have explored the effect of thyroid hormones (THs) and urinary iodine concentration (UIC) on serum lipid levels. However, the association between iodine intake and dyslipidemia has not been well established. This study aimed to investigate the relationship between water iodine concentration (WIC) and dyslipidemia, including hypercholesterolemia, hypertriglyceridemia, low high-density lipoprotein cholesterol (HDL-C) and high low-density lipoprotein cholesterol (LDL-C). A cross-sectional survey was conducted involving 409, 390 and 436 adults (≥18 years) from the iodine-deficient (median water iodine, MWI < 10 µg/L), iodine-adequate (MWI between 40 and 100 µg/L) and iodine-excess (MWI > 100 µg/L) areas, respectively. WIC, total cholesterol (TC), triglyceride (TRIG), HDL-C and LDL-C were measured. The prevalence of dyslipidemia were calculated based on the level of WIC using the chi-square method. To further explore whether prevalence was associated with WIC, simple linear regressions and multiple logistic regression models were used. Compared to those with WIC of 40–100 µg/L, a WIC of >100 µg/L was found to be protective associated with against the occurrence of hypertriglyceridemia [adjusted odds ratio (AOR) = 0.649, 95% confidence interval (CI): 0.455–0.924] and low HDL-C (AOR = 0.429, 95% CI: 0.264–0.697). The prevalence of hypertriglyceridemia, low HDL-C and high LDL-C as a function of WIC was found to be an inverted U-shaped association with a zenith at a WIC of 40–100 µg/L. Collectively, our research showed that serum lipid levels are related to WIC. The benefit effect association between WIC and dyslipidemia appears in cases of iodine excess (>100 µg/L).