Residential exposure to traffic is associated with coronary atherosclerosis
Residential exposure to traffic is associated with coronary atherosclerosis
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DOI：
10.1161/circulationaha.107.693622
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发表时间：
2007-07-31
期刊：
影响因子：
37.8
通讯作者：
Joeckel, K.-H.
中科院分区：
文献类型：
--
作者：
Hoffmann, B.;Moebus, S.;Joeckel, K.-H.
长期暴露于细颗粒物（PM2.5）空气污染可能加速动脉粥样硬化的发展和进展。我们调查的协会长期住宅暴露于交通和细颗粒物与冠状动脉atherosclerosis.Methods和结果的程度-我们使用的基线数据4494名参与者（年龄45至74岁）从德国海因茨Nixdorf召回研究，以人口为基础的，前瞻性队列研究，开始于2000年。为了评估暴露差异，计算了住宅和主要道路之间的距离，并将来自小规模分散模型的年度细颗粒物浓度分配给每个地址。主要结果是通过电子束计算机断层扫描评估冠状动脉钙化（CAC）。我们通过logistic和线性回归分析评估了空气污染与CAC之间的关系，控制了冠状动脉粥样硬化的个体水平危险因素。与居住在距离主要道路> 200米的参与者相比，居住在50米、51米至100米和101米至200米范围内的参与者的优势比为1.63（95% CI，1.14 - 2.33）、1.34（95% CI，1.00 - 1.79）和1.08（95% CI，0.85 - 1.39）。住宅与主要道路之间的距离减少一半与CAC增加7.0%（95%CI，0.1至14.4）相关。细颗粒物暴露与CAC只有在没有全职工作至少5 years.Conclusions -长期住宅暴露于高流量与冠状动脉粥样硬化的程度。
Background - Long-term exposure to fine-particulate-matter (PM2.5) air pollution may accelerate the development and progression of atherosclerosis. We investigated the associations of long-term residential exposure to traffic and fine particulate matter with the degree of coronary atherosclerosis.Methods and Results - We used baseline data on 4494 participants ( age 45 to 74 years) from the German Heinz Nixdorf Recall Study, a population-based, prospective cohort study that started in 2000. To assess exposure differences, distances between residences and major roads were calculated, and annual fine particulate matter concentrations, derived from a small-scale dispersion model, were assigned to each address. The main outcome was coronary artery calcification (CAC) assessed by electron-beam computed tomography. We evaluated the association between air pollution and CAC with logistic and linear regression analyses, controlling for individual level risk factors of coronary atherosclerosis. Compared with participants living > 200 m away from a major road, participants living within 50, 51 to 100, and 101 to 200 m had odds ratios of 1.63 (95% CI, 1.14 to 2.33), 1.34 (95% CI, 1.00 to 1.79), and 1.08 (95% CI, 0.85 to 1.39), respectively, for a high CAC ( CAC above the age- and gender-specific 75th percentile). A reduction in the distance between the residence and a major road by half was associated with a 7.0% (95% CI, 0.1 to 14.4) higher CAC. Fine particulate matter exposure was associated with CAC only in subjects who had not been working full-time for at least 5 years.Conclusions - Long-term residential exposure to high traffic is associated with the degree of coronary atherosclerosis.