Croconaine nanoparticles with enhanced tumor accumulation for multimodality cancer theranostics
Croconaine nanoparticles with enhanced tumor accumulation for multimodality cancer theranostics
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Croconaine 纳米粒子可增强肿瘤累积，用于多模式癌症治疗诊断
DOI：
10.1016/j.biomaterials.2017.03.009
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发表时间：
2017-06-01
期刊：
影响因子：
14
通讯作者：
Sun, Xiaolian
中科院分区：
文献类型：
--
作者：
Tang, Longguang;Zhang, Fuwu;Sun, Xiaolian
提出了一种由聚乙二醇修饰的croconaine染料（CR780）自组装的新型纳米粒子，用于光声(PA)/近红外（NIR）荧光成像引导光热治疗（PTT）。简单的聚乙二醇修饰使CR780具有两亲性，并使其自组装成定义明确、均匀的纳米结构，通过控制组装条件可调节其尺寸。CR780-PEG5K不仅表现出小分子的优势（包括快速分布到不同器官、快速肾脏清除、极少积聚到正常组织），而且表现出纳米材料的优势（包括高生理稳定性、多模式治疗能力、高肿瘤蓄积和滞留）。这些易于合成的分子纳米探针作为一种多功能治疗剂显示出巨大的临床转化潜力。(C) 2017 Elsevier Ltd.版权所有。
A novel nanoparticle self-assembled by polyethylene glycol (PEG) modified croconaine dye (CR780) is presented for photoacoustic (PA)/near-infrared (NIR) fluorescence imaging-guided photothermal therapy (PTT). The simple PEGylation made CR780 amphiphilic, and led to their self-assembly into well-defined and uniform nanostructures with size tunable by controlling the assembly conditions. The CR780-PEG5K not only displayed the strength of small molecules (including rapid distribution to different organs, fast renal clearance and minimal accumulation to normal tissues), but also demonstrated the advantages of nanomaterials (including high physiological stability, multimodal theranostic ability, high tumor accumulation and retention). These facilely synthesized molecular nanoprobes showed great clinical translation potential as a versatile theranostic agent. (C) 2017 Elsevier Ltd. All rights reserved.