Hemiterpene glucosides with anti-platelet aggregation activities from Ilex pubescens
Hemiterpene glucosides with anti-platelet aggregation activities from Ilex pubescens
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DOI：
10.1021/np049735y
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发表时间：
2005-03-01
影响因子：
5.1
通讯作者：
Liu, L
中科院分区：
文献类型：
--
作者：
Jiang, ZH;Wang, JR;Liu, L
从毛冬青（Ilex pubescens）根中分离得到两个新的半萜苷，命名为毛冬青苷A和B。根据光谱和化学方法，分别鉴定了它们的结构为2-（transaffeoyloxy）甲基-3-羟基-1-丁烯-4-O-β-D-吡喃葡萄糖苷和2-羟甲基-3-咖啡酰氧基-1-丁烯-4-O-β-D-吡喃葡萄糖苷。毛蕊苷A和B的药理学研究表明，两者都具有较强的抗血小板聚集活性。
Two new hemiterpene glucosides named pubescenosides A and B were isolated from the root of Ilex pubescens. Their structures were elucidated on the basis of spectroscopic and chemical evidence as 2-(transcaffeoyloxy)methyl-3-hydroxy-l-butene-4-0- -D-glucopyranoside and 2-hydroxymethyl-3-caffeoyloxy-1-butene-4-O-beta-D-glucopyranoside, respectively. Pharmacological investigation on pubescenosides A and B indicated that both possess potent anti-platelet aggregation activities.