THIONAPHTHEN DERIVATIVES .3. CHARACTERISATION OF SOME 5-SUBSTITUTED DERIVATIVES
THIONAPHTHEN DERIVATIVES .3. CHARACTERISATION OF SOME 5-SUBSTITUTED DERIVATIVES
复制标题
DOI：
10.1039/jr9600000938
复制
发表时间：
1960-01-01
期刊：
影响因子：
--
通讯作者：
REID, ST
中科院分区：
文献类型：
--
作者：
MARTINSMITH, M;REID, ST
在研究萘硫醚衍生物作为可能的生物活性化合物时，有必要对一些5-取代萘硫醚衍生物进行结构鉴定。5-羟基硫代萘在冷乙酸中经一硝化反应生成5-羟基-4-硝基硫代萘，其结构是由已知的5-氨基-硝基硫代萘采用氨基亲核取代的替代合成法证明的。5-羟基硫代萘-2-羧酸也被证明是直接硝化。l-位置，产品与真实的
IN an investigation of thionaphthen derivatives as possible biologically active compounds, it was necessary to characterise various derivatives of some 5-substituted thionaphthens. 5-Hydroxythionaphthen underwent mononitration in cold acetic acid to form 5-hydroxy-4-nitrothionaphthen, the constitution of which was proved by an alternative synthesis from the known 5-amino-knitrothionaphthen employing nucleophilic displacement of the amino-group. 5-Hydroxythionaphthen-2-carboxylic acid was shown also to be nitrated directly in the. l-position, the product being identical with an authentic