The value of isolated populations in genetic studies of allergic diseases
The value of isolated populations in genetic studies of allergic diseases
复制标题
分离群体在过敏性疾病遗传学研究中的价值
DOI：
--
复制
发表时间：
2002
影响因子：
2.8
通讯作者：
T. Laitinen
中科院分区：
文献类型：
--
作者：
T. Laitinen
哮喘和其他由免疫球蛋白E介导的特应性疾病在人群中非常常见，在疾病的遗传中具有一致但相当小的遗传成分(λ同胞3-5)。到目前为止，哮喘相关性状的全基因组基因图谱研究还没有取得与孟德尔疾病基因定位克隆相同的成功。许多疾病易感等位基因被认为与这些表型的发生有关，但目前我们还不清楚它们的遗传结构。由于与更多的混合群体相比，等位基因多样性降低和更远距离的连锁不平衡，隔离群体可能提供了一个独特的机会，来模拟这些易导致常见疾病(如哮喘)的复杂遗传事件的简化图景，这些疾病表现出家族聚集性，但不遵循简单的孟德尔遗传模式。
Asthma and other IgE-mediated atopic disorders are extremely common in the population, with a consistent, but rather small, genetic component (λsib 3-5) in the inheritance of the disease. So far, genome-wide gene mapping studies in asthma-related traits have not achieved the same success as the positional cloning of genes for Mendelian diseases. Many disease predisposing alleles are believed to be involved in the development of these phenotypes, but at present we do not understand their genetic architecture. As a result of reduced allelic diversity and longer-range linkage disequilibrium compared with more mixed populations, isolated populations may offer a unique opportunity to model a simplified picture of these complex genetic events predisposing to common diseases, such as asthma, which demonstrate familial clustering, but do not follow a simple Mendelian mode of inheritance.
DOI：
10.1164/ajrccm.164.11.2101086
发表时间：
2001-12-01
影响因子：
24.7
作者：
Hakonarson, H;Bjornsdottir, US;Stefansson, K
通讯作者：
Stefansson, K
影响因子：
9.8
作者：
Ober, C;Abney, M;McPeek, MS
通讯作者：
McPeek, MS