The effect of a high-carbohydrate meal on postprandial thermogenesis and sympathetic nervous system activity in boys with a recent onset of obesity
The effect of a high-carbohydrate meal on postprandial thermogenesis and sympathetic nervous system activity in boys with a recent onset of obesity
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DOI：
10.1016/j.metabol.2004.10.009
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发表时间：
2005-04-01
影响因子：
9.8
通讯作者：
Moritani, T
中科院分区：
文献类型：
--
作者：
Nagai, N;Sakane, N;Moritani, T
本研究的目的是调查肥胖男孩的食物热效应（TEF）和交感神经系统（SNS）活动。研究人员对 10 名肥胖男孩（9.2 +/- 0.4 岁）和 13 名瘦男孩（8.8 +/- 0.4 岁）进行了能量消耗和脂肪氧化检查，在高碳水化合物（HC；70% 碳水化合物、20% 脂肪和 10% 蛋白质）或高脂肪（HF；20% 碳水化合物、70% 脂肪和 10% 蛋白质）膳食后 3 小时内通过间接量热法测量。 随机2个不同的日子。通过心率变异性的功率谱分析来评估 SNS 的活动。食用 HC 餐后，肥胖男孩的 TEF（以消耗能量的百分比表示）显着低于瘦男孩；然而，在高频餐后并没有观察到这种差异。多重回归分析表明，肥胖是导致 HC 餐引起的 TEF 差异的一个重要变量。此外，与其余肥胖和瘦男孩相比，在吃HC餐后，最近出现肥胖（持续时间<3年）的男孩表现出较低的TEF以及心率变异性（体温调节SNS功能指数）的极低频成分降低。总之，肥胖男孩对 HF 餐具有正常的代谢和交感反应，但对 HC 餐的生热反应减弱，尤其是在肥胖的早期阶段。 (c) 2005 Elsevier Inc. 保留所有权利。
The purpose of the present study was to investigate the thermic effect of food (TEF) and sympathetic nervous system (SNS) activity in obese boys. Ten obese (9.2 +/- 0.4 years) and 13 lean boys (8.8 +/- 0.4 years) were examined for energy expenditure and fat oxidation measured via indirect calorimetry for 3 hours after a high-carbohydrate (HC; 70% carbohydrate, 20% fat, and 10% protein) or a high-fat (HF; 20% carbohydrate, 70% fat, and 10% protein) meal served on 2 different days at random. The activity of the SNS was assessed by means of a power spectral analysis of the heart rate variability. The TEF, expressed as a percentage of the consumed energy, was significantly lower in obese boys than in lean boys after the HC meal; however, such a difference was not observed after the HF meal. Multiple regession analysis revealed that obesity was a significant variable contributing to the variances in the TEF induced by the HC meal. Moreover, after the HC meal, the boys with a recent onset of obesity (duration, < 3 years) manifested a lower TEF as well as a reduced very low frequency component of the heart rate variability, an index of thermoregulatory SNS functions, compared with the remaining obese and lean boys. In conclusion, obese boys possessed normal metabolic and sympathetic responses to the HF meal but showed a diminished thermogenic response to the HC meal, especially during the early phase of obesity. (c) 2005 Elsevier Inc. All rights reserved.