Feasibility of Magnetic Resonance Elastography for the Pancreas at 3T
Feasibility of Magnetic Resonance Elastography for the Pancreas at 3T
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DOI：
10.1002/jmri.24995
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发表时间：
2016-02-01
影响因子：
4.4
通讯作者：
Sakahara, Harumi
中科院分区：
文献类型：
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作者：
Itoh, Yohei;Takehara, Yasuo;Sakahara, Harumi
目的：1）评估弹力带支撑上腹部对于减少3.0T磁共振弹性成像（MRE）误算的胰腺面积的有效性； 2）测试MRE是否能够检测正常胰腺和局灶性胰腺疾病之间的硬度差异。材料和方法：使用最初的8名正常志愿者，比较带松紧带和不带松紧带的MRE在3.0T MRI上的误算面积。然后，使用弹性带对 14 名志愿者和 11 名患有局灶性胰腺病变的患者进行了正常胰腺的 MRE 测量。 结果：使用弹性带时正确计算区域的中位数（95% 置信区间 [CI]）百分比为 57.4%（32.9-63.0），不使用弹性带时为 35.3%（11.4-60.4）（P=0.0078）。正常志愿者每个胰腺节段的硬度（平均值+/-SE）为头部2.37+/-0.16 kPa，身体2.46+/-0.17 kPa，尾部2.58+/-0.26 kPa。 7例胰腺癌的硬度为6.06+/-0.49 kPa，高于正常志愿者的整体胰腺硬度（2.47+/-0.11 kPa，P < 0.0001）。胰腺病灶头部6.03±0.42 kPa、体部5.57±0.82 kPa、尾部5.9±1.9 kPa的硬度也高于正常志愿者相应节段（分别P=0.0011、0.0029和0.029）。结论：松紧带的使用减少了胰腺硬度的误算。磁共振成像显示正常胰腺和胰腺病变之间的硬度差异。
Purpose: 1) To assess the usefulness of an elastic belt bracing the upper abdomen for reducing the miscalculated areas of the pancreas on 3.0T magnetic resonance elastography (MRE); 2) to test whether MRE can detect difference of stiffness between normal pancreas and the focal pancreatic diseases.Materials and Methods: Using an initial eight normal volunteers, miscalculated areas were compared between MRE with the elastic belt and without the belt on 3.0T MRI. Then, using the belt, MRE of the normal pancreas was measured using 14 volunteers and 11 patients with focal pancreatic lesions.Results: The median (95% confidence interval [CI]) percentages of correctly calculated areas were 57.4% (32.9-63.0) with the elastic belt and 35.3% (11.4-60.4) without the belt (P=0.0078). The stiffness of each pancreatic segment of the normal volunteers (mean+/-SE) was 2.37+/-0.16 kPa for the head, 2.46+/-0.17 kPa for the body, and 2.58+/-0.26 kPa for the tail. The stiffness of seven pancreatic cancers was 6.06+/-0.49 kPa, which was higher than the overall pancreatic stiffness of the normal volunteers (2.47+/-0.11 kPa, P < 0.0001). Stiffness of the pancreatic lesions in the head of 6.03+/-0.42 kPa, body of 5.57+/-0.82 kPa, and tail of 5.9+/-1.9 kPa were also higher than those of corresponding segments of the normal volunteers (P=0.0011, 0.0029, and 0.029, respectively).Conclusion: With the elastic belt, miscalculation of the pancreatic stiffness was reduced. MRE showed differences of stiffness between normal pancreas and pancreatic lesions.