ACIDIC FIBROBLAST GROWTH-FACTOR PREVENTS POST-AXOTOMY NEURONAL DEATH OF THE NEWBORN RAT FACIAL-NERVE
ACIDIC FIBROBLAST GROWTH-FACTOR PREVENTS POST-AXOTOMY NEURONAL DEATH OF THE NEWBORN RAT FACIAL-NERVE
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DOI：
10.1016/0304-3940(95)11926-n
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发表时间：
1995-09-15
影响因子：
2.5
通讯作者：
GIMENEZGALLEGO, G
中科院分区：
文献类型：
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作者：
CUEVAS, P;CARCELLER, F;GIMENEZGALLEGO, G
轴突切开术后面部运动神经元的死亡为研究神经营养因子提供了有用的工具，可以防止体内运动神经元丧失。在新生大鼠的后神经分支前的右面神经躯干在其颅外出口处转换，并在轴突切开术中局部处理，并在轴突切开术中，含有含琼脂糖或甲氯硝酸盐或酸性成纤维成纤维细胞生长因子（AFGF）的车辆溶液（AFGF）。酸性FGF治疗将面部运动神经元的存活率从18％提高到70％。这些结果表明，AFGF是体内运动神经元的神经营养因子，该生长因子可能为防止损伤运动神经元丧失的治疗发展提供新的基础。
The death of facial motoneurons after axotomy provides a useful tool for studying neurotrophic factors which could prevent motoneuron loss in vivo. The right facial nerve trunk before the postauricular nerve branching of newborn rats was transected at its extracranial exit, and topically treated, at the axotomy site, with either a vehicle solution containing agarose or sucralfate, or acidic fibroblast growth factor (aFGF). Acidic FGF treatment increased the survival of the facial motoneurons from 18% to 70%. These results suggest that aFGF is a neurotrophic factor for motoneurons in vivo and that this growth factor may provide a new basis for the development of treatments to prevent the loss of damaged motoneurons.