Association of creative achievement with cognitive flexibility by a combined voxel-based morphometry and resting-state functional connectivity study
Association of creative achievement with cognitive flexibility by a combined voxel-based morphometry and resting-state functional connectivity study
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DOI：
10.1016/j.neuroimage.2014.08.008
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发表时间：
2014-11-15
期刊：
影响因子：
5.7
通讯作者：
Qiu, Jiang
中科院分区：
文献类型：
--
作者：
Chen, Qunlin;Yang, Wenjing;Qiu, Jiang
虽然研究人员普遍认为创造力涉及到新颖和有用的产品的生产，但由于所涉及的认知过程的复杂性，创造力的神经基础仍然难以捉摸。最近的研究表明，高创造力的人表现出更多的认知灵活性。然而，支持创造力和认知灵活性之间的关系的直接证据很少使用结构和功能神经影像技术进行调查。我们使用了基于体素的形态测量和静息状态功能连接（rsFC）分析，以探讨个体创造力之间的关系评估的创造性成就问卷（CAQ），区域灰质体积（GMV），以及内在的功能连接。结果表明，CAQ得分与扣带回吻侧前部（ACC）和延伸至辅助运动区的双侧背侧ACC（dACC）的GMV呈负相关，与双侧额上级回和腹内侧前额叶皮层（vmPFC）的GMV呈正相关。进一步的功能连接分析显示，更高的创造性成就与dACC和内侧上级额回（mSFG），右额中回，左眶额回之间的rsFC的强度呈负相关。此外，dACC-mSFG连接性与CAQ评分之间的关联是由认知灵活性介导的，并通过任务切换范式进行评估。这些发现表明，创造性成就的个体差异与认知灵活性和刻意创造性加工的大脑结构和相应的内在功能连接有关。此外，dACC-mSFG连接可能通过其对认知灵活性的影响来影响创造性成就。(c)2014爱思唯尔公司All rights reserved.
Although researchers generally concur that creativity involves the production of novel and useful products, the neural basis of creativity remains elusive due to the complexity of the cognitive processes involved. Recent studies have shown that highly creative individuals displayed more cognitive flexibility. However, direct evidence supporting the relationship between creativity and cognitive flexibility has rarely been investigated using both structural and functional neuroimaging techniques. We used a combined voxel-based morphometry and resting-state functional connectivity (rsFC) analysis to investigate the relationship between individual creativity ability assessed by the creative achievement questionnaire (CAQ), and regional gray matter volume (GMV), as well as intrinsic functional connectivity. Results showed that CAQ scores negatively correlated with GMV in the rostral anterior cingulate cortex (ACC) and the bilateral dorsal ACC (dACC) extending to supplementary motor area, but positively correlated with GMV in the bilateral superior frontal gyrus and ventral medial prefrontal cortex (vmPFC). Further functional connectivity analysis revealed that higher creative achievement was inversely associated with the strength of rsFC between the dACC and medial superior frontal gyrus (mSFG), right middle frontal gyrus, and left orbito-frontal insula. Moreover, the association between the dACC-mSFG connectivity and CAQ scores was mediated by cognitive flexibility, assessed by a task-switching paradigm. These findings indicate that individual differences in creative achievement are associated with both brain structure and corresponding intrinsic functional connectivity involved in cognitive flexibility and deliberate creative processing. Furthermore, dACC-mSFG connectivity may affect creative achievement through its impact on cognitive flexibility. (c) 2014 Elsevier Inc. All rights reserved.