A Randomized Controlled Trial of Personalized Text Message Reminders to Promote Medication Adherence Among HIV-Positive Adolescents and Young Adults.
A Randomized Controlled Trial of Personalized Text Message Reminders to Promote Medication Adherence Among HIV-Positive Adolescents and Young Adults.
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DOI：
10.1007/s10461-015-1192-x
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发表时间：
2016-05
影响因子：
4.4
通讯作者：
Rice D
中科院分区：
文献类型：
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作者：
Garofalo R;Kuhns LM;Hotton A;Johnson A;Muldoon A;Rice D
HIV 阳性青少年和年轻人的用药依从性往往不佳，但很少有改善该群体依从性的干预措施显示出有效的证据。我们进行了一项双向、个性化每日短信干预的随机试验，以提高 N=105 名 16-29 岁、依从性较差的 HIV 阳性青少年和年轻人对抗逆转录病毒治疗 (ART) 的依从性。在第 3 个月和第 6 个月，通过自我报告的视觉模拟量表（VAS；0-100%）评估对 ART 的依从性，以评估平均依从水平和≥ 90% 依从率。 6 个月干预期间的平均效果估计对于 ≥ 90% 的依从性具有显着意义（OR=2.12，95% CI=1.01–4.45，p<.05），并维持在 12 个月（干预后 6 个月）。干预的满意度得分非常高。这些结果表明了这种方法的可行性和初步有效性。鉴于研究的局限性，有必要对这种干预措施进行额外测试，作为更大规模临床试验的一部分，以客观和/或临床结果衡量依从性。
HIV-positive adolescents and young adults often experience suboptimal medication adherence, yet few interventions to improve adherence in this group have shown evidence of efficacy. We conducted a randomized trial of a two-way, personalized daily text messaging intervention to improve adherence to antiretroviral therapy (ART) among N=105 poorly adherent HIV-positive adolescents and young adults, ages 16–29. Adherence to ART was assessed via self-reported visual analogue scale (VAS; 0–100%) at 3 and 6-months for mean adherence level and proportion ≥ 90% adherent. The average effect estimate over the 6-month intervention period was significant for ≥ 90% adherence (OR=2.12, 95% CI=1.01–4.45, p<.05) and maintained at 12-months (6 months post-intervention). Satisfaction scores for the intervention were very high. These results suggest both feasibility and initial efficacy of this approach. Given study limitations, additional testing of this intervention as part of a larger clinical trial with objective and/or clinical outcome measures of adherence is warranted.