Expression of SIRT1 and SIRT3 varies according to age in mice.
Expression of SIRT1 and SIRT3 varies according to age in mice.
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DOI：
10.5115/acb.2015.48.1.54
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发表时间：
2015-03
影响因子：
1.1
通讯作者：
Kim H
中科院分区：
文献类型：
--
作者：
Kwon Y;Kim J;Lee CY;Kim H
Sirtuins（SIRTs）参与多种细胞过程，包括与衰老、癌症和多种细胞功能（包括细胞周期进展、DNA修复和细胞增殖）相关的那些过程。SIRT已被证明可以延长酵母寿命，尽管目前对小鼠器官中SIRT的表达知之甚少。在本研究中，我们特别感兴趣的是确定年轻小鼠和老年小鼠之间SIRT表达的差异。具体来说，我们研究了SIRT1和SIRT3的表达在肾脏，肺，皮肤，脂肪组织，和脾脏的6个月大和24个月大的小鼠使用免疫组织化学染色。与年轻小鼠相比，24月龄大鼠肾脏、肺和脾组织中SIRT1的表达增加，而脂肪、肾脏和肺组织中SIRT3的表达减少。我们的研究结果表明，衰老与SIRT1和SIRT3表达模式的改变有关。此外，我们注意到SIRT1和SIRT3的表达模式因器官而异。总之，这项研究的结果表明SIRTs可能参与与衰老相关的疾病。
Sirtuins (SIRTs) are involved in multiple cellular processes including those related to aging, cancer, and a variety of cellular functions including cell cycle progression, DNA repair, and cellular proliferation. SIRTs have been shown to extend the yeast life span, although there is presently little known about SIRT expression in the organs of mice. In the present study, we were especially interested in identifying differences in SIRT expression between young mice and aged mice. Specifically, we investigated the expression of SIRT1 and SIRT3 in the kidney, lung, skin, adipose tissue, and spleens of 6-month-old and 24-month-old mice using immunohistochemical staining. Compared with that in younger mice, the expression of SIRT1 in 24-month-old rats was increased in kidney, lung, and spleen tissue, while that of SIRT3 was decreased in adipose, kidney, and lung tissue. The results of our study suggest that aging is associated with altered patterns of expression of SIRT1 and SIRT3. In addition, we noted that the expression patterns of SIRT1 and SIRT3 varied by organ. Taken together, the results of this study suggest the possibility that SIRTs may be involved in diseases associated with aging.