The kit receptor and its ligand, steel factor, as regulators of hemopoiesis.
The kit receptor and its ligand, steel factor, as regulators of hemopoiesis.
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发表时间：
1991-12
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通讯作者：
H. Broxmeyer;R. Maze;Keisuke Miyazawa;C. Carow;Paul C. Hendrie;S. Cooper;G. Hangoc;Saroj Vadhan-Raj;Li Lu
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作者：
H. Broxmeyer;R. Maze;Keisuke Miyazawa;C. Carow;Paul C. Hendrie;S. Cooper;G. Hangoc;Saroj Vadhan-Raj;Li Lu
在显性白斑 (W) 基因座或钢 (Sl) 基因座上携带突变的小鼠品系是贫血的，并且在色素沉着和配子发生方面表现出缺陷。在W突变体中，贫血是由于造血干细胞的缺乏，而在Sl突变体中，贫血是由于骨髓中支持基质细胞的缺乏。 W 基因座编码 c-kit 原癌基因产物，一种具有蛋白酪氨酸激酶活性的细胞表面受体，Sl 基因座编码其配体，一种造血细胞因子，也称为 Steel 因子 (SLF)、肥大细胞生长因子、干细胞因子和 Kit 配体。 SLF可以与许多其他细胞因子协同作用，在体外刺激造血祖细胞的生长，并在动物体内刺激血细胞的产生。在这里，我们回顾了 SLF 的生物活性，特别强调其对造血干细胞和祖细胞的影响。我们还讨论了目前对 SLF 触发信号转导分子的了解，并推测了 SLF 在人类疾病中的潜在治疗应用。
Mouse strains carrying mutations at the Dominant White Spotting (W) locus or the Steel (Sl) locus are anemic and display defects in pigmentation and gametogenesis. In W mutants the anemia is due to a deficiency of hemopoietic stem cells and, in Sl mutants, to a deficiency of supporting stromal cells in the bone marrow. The W locus encodes the c-kit proto-oncogene product, a cell surface receptor with protein-tyrosine kinase activity, and the Sl locus encodes its ligand, a hemopoietic cytokine known variously as Steel factor (SLF), mast cell growth factor, stem cell factor, and Kit ligand. SLF can synergize with a number of other cytokines to stimulate growth of hemopoietic progenitors in vitro and stimulates blood cell production in vivo in animals. Here we review the biological activities of SLF, with particular emphasis on its effects on hemopoietic stem and progenitor cells. We also discuss present knowledge of the molecules involved in SLF-triggered signal transduction, and speculate on potential therapeutic applications for SLF in human disease.