Action and function of Akkermansia muciniphila in microbiome ecology, health and disease
Action and function of Akkermansia muciniphila in microbiome ecology, health and disease
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DOI：
10.1016/j.bpg.2017.10.001
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发表时间：
2017-12-01
影响因子：
3.2
通讯作者：
Belzer, Clara
中科院分区：
文献类型：
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作者：
Ottman, Noora;Geerlings, Sharon Y.;Belzer, Clara
嗜粘蛋白阿克曼氏菌的发现为在下一代治疗产品中使用这种丰富的肠道共生体以及靶向微生物群动力学开辟了新的途径。A.已知嗜粘蛋白菌定殖于人肠的粘膜层，在那里它触发宿主代谢和免疫应答。A.嗜粘蛋白菌在增加粘液厚度和增强肠道屏障功能方面特别有效。结果宿主代谢标志物得到改善。宿主调节的机制被认为涉及外膜组成，包括A的IV型皮利。直接向宿主免疫受体发出信号。同时，A.嗜粘蛋白菌导致产生对宿主和微生物群成员有益的短链脂肪酸。这有助于宿主-微生物和微生物-微生物互养。嗜粘蛋白菌（muciniphila）是粘液层中的关键物种，刺激有益的粘膜微生物网络。粘蛋白的特性和粘蛋白适应，ii）其作为粘膜微生物组中的关键物种的作用，和iii）其在宿主健康中的作用。(C)2017由Elsevier Ltd.出版
The discovery of Akkermansia muciniphila has opened new avenues for the use of this abundant intestinal symbiont in next generation therapeutic products, as well as targeting microbiota dynamics. A. muciniphila is known to colonize the mucosal layer of the human intestine where it triggers both host metabolic and immune responses. A. muciniphila is particularly effective in increasing mucus thickness and increasing gut barrier function. As a result host metabolic markers ameliorate. The mechanism of host regulation is thought to involve the outer membrane composition, including the type IV pili of A. muciniphila, that directly signal to host immune receptors. At the same time the metabolic activity of A. muciniphila leads to the production of short chain fatty acids that are beneficial to the host and microbiota members. This contributes to host-microbiota and microbe-microbe syntrophy The mucolytic activity and metabolite production make A. muciniphila a key species in the mucus layer, stimulating beneficial mucosal microbial networks.This well studied member of the microbiota has been studied in three aspects that will be further described in this review: i) A. muciniphila characteristics and mucin adaptation, ii) its role as key species in the mucosal microbiome, and iii) its role in host health. (C) 2017 Published by Elsevier Ltd.