Circulating peripheral blood fibrocytes in human fibrotic interstitial lung disease
Circulating peripheral blood fibrocytes in human fibrotic interstitial lung disease
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DOI：
10.1016/j.bbrc.2006.11.149
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发表时间：
2007-02-02
影响因子：
3.1
通讯作者：
Strieter, Robert M.
中科院分区：
文献类型：
--
作者：
Mehrad, Borna;Burdick, Marie D.;Strieter, Robert M.
纤维化间质性肺病是以肺功能进行性下降为特征的病因不明的疾病。纤维细胞是骨髓来源的循环祖细胞，能够分化成各种间充质细胞类型。先前的研究表明，在肺纤维化动物模型中，纤维细胞通过CXCL12-CXCR4趋化因子轴向肺输送。因此，我们评估了纤维细胞在纤维化间质性肺病患者中的相关性。我们发现CXCL12在肺纤维化患者的肺和血浆中表达增强。CXCL12水平与这些患者外周血中循环纤维细胞数量增加一个数量级相关。肺间质性疾病患者的大多数循环纤维细胞对肌成纤维细胞标志物α -平滑肌肌动蛋白呈阴性，表明其表型相对未分化。综上所述，这些数据表明纤维细胞参与了人肺纤维化的发病机制。(c) 2006爱思唯尔公司版权所有。
Fibrotic interstitial lung diseases are illnesses of unknown cause characterized by progressive decline in lung function. Fibrocytes are bone marrow-derived, circulating progenitor cells capable of differentiating into diverse mesenchymal cell types. Prior work has shown fibrocytes to traffic to the lung via the CXCL12-CXCR4 chemokine axis in an animal model of pulmonary fibrosis. We therefore assessed the relevance of fibrocytes in patients with fibrotic interstitial lung disease. We found enhanced expression of CXCL12 in both the lungs and plasma of patients with lung fibrosis. CXCL12 levels were associated with an order of magnitude higher number of circulating fibrocytes in the peripheral blood of these patients. Most of the circulating fibrocytes in patients with interstitial lung diseases were negative for the myofibroblast marker alpha-smooth muscle actin, suggesting a relatively undifferentiated phenotype. Taken together, these data suggest that fibrocytes are involved in the pathogenesis of human lung fibrosis. (c) 2006 Elsevier Inc. All rights reserved.