Microbial antagonism: a neglected avenue of natural products research
Microbial antagonism: a neglected avenue of natural products research
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DOI：
10.1016/s0168-1656(99)00054-1
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发表时间：
1999-04-30
影响因子：
4.1
通讯作者：
Boyd, KG
中科院分区：
文献类型：
--
作者：
Burgess, JG;Jordan, EM;Boyd, KG
微生物之间对海洋环境中的空间和营养物质的竞争是一种强大的选择力，它导致了多种在表面定植和生长的有效策略的演变。我们对生活在海洋藻类或无脊椎动物表面的海洋附生细菌的化学生态学特别感兴趣。从苏格兰沿海水域的各种海藻和无脊椎动物中分离出超过 400 株表面相关细菌，其中 35% 能够产生抗菌化合物。这比自由生活的海洋分离菌或土壤细菌的比例要高得多。此外，许多通常不产生抗生素的菌株可以通过将它们暴露于少量活细胞、其他细菌培养物的上清液或其他化学物质来诱导产生抗生素。因此，能够产生抗生素的菌株数量似乎比之前想象的要多得多。抗生素的产生是由其他海洋表生物以及陆生人类病原体（例如枯草芽孢杆菌、大肠杆菌和铜绿假单胞菌）引起的。了解这种类型的化学诱导和调节抗菌化合物非组成性分泌的因素将有助于设计更有效的策略来寻找新的化疗抗生素。 (C) 1999 Elsevier Science B.V. 保留所有权利。
Competition amongst microbes for space and nutrients in the marine environment is a powerful selective force which has led to the evolution of a variety of effective strategies for colonising and growing on surfaces. We are particularly interested in the chemical ecology of marine epibiotic bacteria which live on the surfaces of marine algae or invertebrates. Over 400 strains of surface-associated bacteria from various species of seaweed and invertebrate from Scottish coastal waters were isolated and 35% of them shown to produce antimicrobial compounds. This is a much higher proportion than free living marine isolates or soil bacteria. In addition, many strains which did not normally produce antibiotics could be induced to do so by exposing them to small amounts of live cells, supernatants from other bacterial cultures or other chemicals. Thus the number of strains able to produce antibiotics appears to be much higher than previously thought. Induction of antibiotic production was elicited by other marine epibionts and also by terrestrial human pathogens such as Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa. An understanding of this type of chemical induction and the factors regulating non-constitutive secretion of antimicrobial compounds will allow more effective strategies for searching for new chemotherapeutic antibiotics to be designed. (C) 1999 Elsevier Science B.V. All rights reserved.