Neural representations of faces and limbs neighbor in human high-level visual cortex: evidence for a new organization principle.
Neural representations of faces and limbs neighbor in human high-level visual cortex: evidence for a new organization principle.
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DOI：
10.1007/s00426-011-0392-x
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发表时间：
2013-01
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影响因子：
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通讯作者：
Grill-Spector K
中科院分区：
文献类型：
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作者：
Weiner KS;Grill-Spector K
在猴子的神经生理学和光学成像研究以及在猴子和人类的功能性磁共振成像（fMRI）研究中发现，颞下皮层的神经反应集中在生物学相关类别的图像上，如面部和四肢。使用比过去的研究（3-5 mm体素）更高分辨率（1.5 mm体素）的fMRI扫描方法，我们最近报道了一个多个面部和肢体选择性区域的网络，这些区域在人类腹侧颞叶皮层（Weiner和Grill-Spector，Neuroimage，52（4）：1559-1573，）和外侧枕颞叶皮层（Weiner和Grill-Spector，Neuroimage，56（4）：2183-2199，）中彼此相邻。在这里，我们扩展了这些发现揭示的高级视觉皮层的三个基本组织原则：（1）功能区解剖位置的一致性，（2）功能区之间保留的空间关系，以及（3）面部和肢体的地形组织，选择性区域相邻和交替集群。我们强调这种结构的影响，在比较功能的大脑组织之间典型和非典型人群。我们得出结论，一个新的模型，高层次的视觉皮层组成的腹侧，侧，背侧组件，多模态处理有关的视觉，动作，触觉，语言收敛在侧通路。本文的在线版本（doi：10.1007/s 00426 -011-0392-x）包含补充材料，可供授权用户使用。
Neurophysiology and optical imaging studies in monkeys and functional magnetic resonance imaging (fMRI) studies in both monkeys and humans have localized clustered neural responses in inferotemporal cortex selective for images of biologically relevant categories, such as faces and limbs. Using higher resolution (1.5 mm voxels) fMRI scanning methods than past studies (3–5 mm voxels), we recently reported a network of multiple face- and limb-selective regions that neighbor one another in human ventral temporal cortex (Weiner and Grill-Spector, Neuroimage, 52(4):1559–1573,) and lateral occipitotemporal cortex (Weiner and Grill-Spector, Neuroimage, 56(4):2183–2199,). Here, we expand on three basic organization principles of high-level visual cortex revealed by these findings: (1) consistency in the anatomical location of functional regions, (2) preserved spatial relationship among functional regions, and (3) a topographic organization of face- and limb-selective regions in adjacent and alternating clusters. We highlight the implications of this structure in comparing functional brain organization between typical and atypical populations. We conclude with a new model of high-level visual cortex consisting of ventral, lateral, and dorsal components, where multimodal processing related to vision, action, haptics, and language converges in the lateral pathway. The online version of this article (doi:10.1007/s00426-011-0392-x) contains supplementary material, which is available to authorized users.