Pyrethroid Pesticide Exposure and Risk of Childhood Acute Lymphocytic Leukemia in Shanghai
Pyrethroid Pesticide Exposure and Risk of Childhood Acute Lymphocytic Leukemia in Shanghai
复制标题
上海地区拟除虫菊酯农药暴露及儿童急性淋巴细胞白血病风险
DOI：
10.1021/es303362a
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发表时间：
2012-12-18
影响因子：
11.4
通讯作者：
Tian, Ying
中科院分区：
文献类型：
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作者：
Ding, Guodong;Shi, Rong;Tian, Ying
中国各地使用大量拟除虫菊酯农药。以前的研究表明，接触农药可能会增加儿童患癌症的风险;然而，很少有研究关注拟除虫菊酯代谢物。我们研究了在儿童尿液中发现的五种拟除虫菊酯类农药的非特异性代谢物，并研究了其与儿童白血病的相关性。我们在2010年至2011年期间在上海进行了一项以医院为基础的儿童急性淋巴细胞白血病（ALL）病例对照研究。该研究包括176名0-14岁的儿童和180名年龄和性别匹配的对照组。与总代谢物和单个代谢物的最低四分位数相比，最高四分位数与ALL风险增加约2倍相关[总代谢物：比值比（OR）= 2.75，95%置信区间（CI），1.43-5.29;顺式-DCCA：OR = 2.21，95% CI，1.16-4.19;反式-DCCA：OR = 2.21，95% CI，1.16-4.19]。OR = 2.33，95%CI，1.23-4.41;和3-PBA：OR = 1.84，95%CI，1.00-3.38]，并且大多数正趋势是显著的（p < 0.05）。我们的研究结果表明，拟除虫菊酯代谢产物的尿液水平可能与儿童ALL的风险升高有关，并代表了以前未报告的儿童白血病定量暴露评估。
Significant amounts of pyrethroid pesticides are used throughout China. Previous studies have suggested that exposure to pesticides may increase the risk of childhood cancer; however, few studies have focused on pyrethroid metabolites. We investigated five nonspecific metabolites of pyrethroid pesticides found in children's urine and examined the correlation with childhood leukemia. We conducted a hospital-based case-control study of childhood acute lymphocytic leukemia (ALL) in Shanghai between 2010 and 2011. The study included 176 children aged 0-14 years and 180 controls matched for age and sex. Compared with those in the lowest quartiles of total and individual metabolites, the highest quartiles were associated with an approximate 2-fold increased risk of ALL [total metabolites: odds ratio (OR) = 2.75, 95% confidence interval (CI), 1.43-5.29; cis-DCCA: OR = 2.21, 95% CI, 1.16-4.19; trans-DCCA: OR = 2.33, 95% CI, 1.23-4.41; and 3-PBA: OR = 1.84, 95% CI, 1.00-3.38], and most of the positive trends were significant (p < 0.05). Our findings suggest that urinary levels of pyrethroid metabolites may be associated with an elevated risk of childhood ALL and represent a previously unreported quantitative exposure assessment for childhood leukemia.