Convergence of noncholinergic afferent neurons in the inferior mesenteric ganglion of the guinea pig.
Convergence of noncholinergic afferent neurons in the inferior mesenteric ganglion of the guinea pig.
复制标题
豚鼠肠系膜下神经节非胆碱能传入神经元的汇聚。
DOI：
10.1016/0304-3940(88)90650-7
复制
发表时间：
1988
影响因子：
2.5
通讯作者：
Kreulen,DL
中科院分区：
文献类型：
--
作者：
Keef,KD;Kreulen,DL
用细胞内技术研究了豚鼠肠系膜下神经节（IMG）内腰结肠神经（LCN）和腰内脏神经（LSN）的主要神经节神经元的非胆碱能神经支配。在最大频率（20 Hz）和次最大刺激电压（2-4 V）下同时刺激LCN和LSN导致缓慢兴奋性突触后电位（EPSP）的总和，表明神经输入的会聚。观察到的总和与次最大（但不是最大）的刺激参数，无论是大幅度或小幅度的最大慢EPSPs的细胞表明，每个神经元有一个单独的最大能力，以响应于非胆碱能递质物质的去甲肾上腺素。研究表明，起源于外周和中枢部位的神经元会聚到主神经节神经元，因此这些神经节神经元必须在IMG中执行重要的整合功能。
The pattern of noncholinergic innervation of principal ganglionic neurons from the lumbar colonic nerve (LCN) and lumbar splanchnic nerve (LSN) in the inferior mesenteric ganglion (IMG) of the guinea pig was studied with intracellular techniques. Simultaneous stimulation of the LCN and LSN at maximum frequency (20 Hz) and submaximal stimulus voltages (2–4 V) led to summation of slow excitatory postsynaptic potential (EPSPs) indicating convergence of neural input. Summation was observed with submaximal (but not maximal) stimulation parameters in cells with either large or small amplitude maximum slow EPSPs suggesting that each neuron has an individual maximum capacity to depolarize in response to noncholinergic transmitter substances. The study indicates that neurons originating at both peripheral and central sites converge onto principal ganglionic neurons, thus these ganglionic neurons must perform a significant integrative function in the IMG.