Enhanced reactivity and delayed recovery of sensorimotor cortex in the novelty seeking personality
Enhanced reactivity and delayed recovery of sensorimotor cortex in the novelty seeking personality
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DOI：
10.1159/000100370
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发表时间：
2006-01-01
影响因子：
3.2
通讯作者：
Yamawaki, Shigeto
中科院分区：
文献类型：
--
作者：
Shishida, Kazuhiro;Hashizume, Akira;Yamawaki, Shigeto
背景：据推测，求新（NS）人格特质与高皮质反应性、较差的抑制控制和/或基底神经节中不同的多巴胺能神经传递有关。体感刺激后，感觉运动皮层中产生的α和β带电振荡显示出短暂的减少（与事件相关的去同步）和随后的增加（与事件相关的同步），这被认为分别反映了皮层激活和抑制/恢复过程。这些振荡变化也被认为受到基底神经节状态和多巴胺能功能的影响。在本研究中，我们研究了通过脑磁图评估正中神经刺激后 NS 人格特质与体感振荡变化之间的关联。方法：从 48 名健康受试者中，我们在气质和性格量表的 NS 维度上选择了 14 名高分者和 14 名年龄和性别匹配的低分者。当受试者以相同的概率和随机的刺激间隔接受右侧或左侧正中神经的电刺激时，记录磁场。对 α 和 β 频带进行频率分析。结果：与低NS组相比，高NS组表现出更大程度的β事件相关去同步以及更大的α和β事件相关同步延迟。结论：这些结果表明，具有高度 NS 特征的个体对于简单的体感刺激具有更高的反应性和感觉运动皮层的延迟恢复。这对于理解他们的探索和冲动行为可能很重要。
Background: The novelty seeking (NS) personality trait is hypothesized to be associated with high cortical reactivity, poor inhibitory control and/or varied dopaminergic neurotransmission in the basal ganglia. After somatosensory stimulation, electrical oscillations in alpha and beta bands generated in the sensorimotor cortex show a short duration decrease (event-related desynchronization) and a subsequent increase (event-related synchronization) that is thought to reflect cortical activation and the inhibitory/recovery process, respectively. These oscillatory changes are also believed to be affected by the status of the basal ganglia and by dopaminergic functions. In the present study, we investigated the association between the NS personality trait and somatosensory oscillatory changes after median nerve stimulation assessed by magnetoencephalography. Methods: From 48 healthy subjects, we selected 14 high scorers and 14 age- and sex-matched low scorers on the NS dimension of the Temperament and Character Inventory. Magnetic fields were recorded while subjects received electrical stimulation of either the right or left median nerve with equal probability and with a randomized interstimulus interval. Frequency analysis was performed on the alpha and beta bands. Results: Compared with the low NS group, the high NS group showed larger magnitude of beta event-related desynchronization and larger latencies of the alpha and beta event-related synchronization. Conclusion: These results suggest that individuals with high degrees of the NS trait have greater reactivity and delayed recovery of the sensorimotor cortex in response to simple somatosensory stimulation. This may be significant for the understanding of their exploratory and impulsive behavior.