Induction of the interleukin 1 receptor antagonist protein by transforming growth factor‐β
Induction of the interleukin 1 receptor antagonist protein by transforming growth factor‐β
复制标题
通过转化生长因子-β 诱导白细胞介素 1 受体拮抗蛋白
DOI：
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发表时间：
1991
影响因子：
5.4
通讯作者：
M. Feldmann
中科院分区：
文献类型：
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作者：
M. Turner;D. Chantry;P. Katsikis;A. Berge;F. Brennan;M. Feldmann
Transforming growth factor‐β1 (TGF‐β1) mediates many immunosuppressive effects on immune cells and can inhibit the production of tumor necrosis factor and interleukin 1 (IL 1). However, TGF‐β1 can stimulate the production of IL6 and platelet‐derived growth factor, indicating that TGF‐β1 initiates complex effects on the production of cytokines. In this report we show that treatment of peripheral blood monocytes with TGF‐β1 leads to the induction of a recently described IL1 receptor antagonist protein (IRAP). The effect of TGF‐β was both dose and time dependent. TGF‐β1 induced de novo synthesis of IRAP, as Northern blotting experiments indicated a rapid and transient induction of the mRNA encoding IRAP. The induction of IRAP suggests a potential mechanism by which some of the inhibitory effects of TGF‐β1 are mediated.
