An Analysis Scheme for 3D Visualization of Positron Emitting Radioisotopes Using Positron Emission Mammography System
An Analysis Scheme for 3D Visualization of Positron Emitting Radioisotopes Using Positron Emission Mammography System
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DOI：
10.3390/app12020823
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发表时间：
2022-01-01
影响因子：
2.7
通讯作者：
Watabe, Hiroshi
中科院分区：
文献类型：
--
作者：
Islam, Md. Rafiqul;Beni, Mehrdad Shahmohammadi;Watabe, Hiroshi
质子射程监测和验证对于通过确保将正确的剂量输送到正确的位置来提高治疗的有效性是重要的。在质子辐照时，通过质子与靶元素的非弹性核相互作用产生不同的正电子发射放射性同位素。最近有报道指出O-16（p，2 p2 n）N-13反应具有较低的阈能，有望用于质子射程验证。在目前的工作中，我们提出了一个分析方案（即，算法）用于正电子发射放射性同位素的提取和三维可视化。建议的一步一步的分析方案进行了测试，使用我们自己的实验获得的动态数据从正电子发射乳腺X射线摄影（PEM）系统（我们开发的PEMGRAPH系统）。实验辐照进行了使用方位变化场（AVF）回旋加速器与80 MeV的单能的类类贝佐斯光束。3D可视化显示了质子诱导的放射性同位素分布的有希望的结果。所提出的方案和开发的工具将是有用的提取和3D可视化的正电子发射放射性同位素和质子范围的监测和核查。
Proton range monitoring and verification is important to enhance the effectiveness of treatment by ensuring that the correct dose is delivered to the correct location. Upon proton irradiation, different positron emitting radioisotopes are produced by the inelastic nuclear interactions of protons with the target elements. Recently, it was reported that the O-16(p,2p2n)N-13 reaction has a relatively low threshold energy, and it could be potentially used for proton range verification. In the present work, we have proposed an analysis scheme (i.e., algorithm) for the extraction and three-dimensional visualization of positron emitting radioisotopes. The proposed step-by-step analysis scheme was tested using our own experimentally obtained dynamic data from a positron emission mammography (PEM) system (our developed PEMGRAPH system). The experimental irradiation was performed using an azimuthally varying field (AVF) cyclotron with a 80 MeV monoenergetic pencil-like beam. The 3D visualization showed promising results for proton-induced radioisotope distribution. The proposed scheme and developed tools would be useful for the extraction and 3D visualization of positron emitting radioisotopes and in turn for proton range monitoring and verification.