C-reactive protein concentration in canine idiopathic polyarthritis
C-reactive protein concentration in canine idiopathic polyarthritis
复制标题
DOI：
10.1292/jvms.68.1275
复制
发表时间：
2006-12-01
影响因子：
1.2
通讯作者：
Tsujimoto, Hajime
中科院分区：
文献类型：
--
作者：
Ohno, Koichi;Yokoyama, Yukiko;Tsujimoto, Hajime
为探讨C反应蛋白（CRP）在特发性多关节炎（IPA）中的临床应用价值，测定了IPA犬的CRP浓度。在诊断时，所有IPA犬的CRP浓度均显著升高，并在初始皮质类固醇治疗后显著降低;这表明CRP可用作IPA病例治疗反应的指标。此外，在诊断后6个月，观察到随访时（治疗开始后6-13天）的CRP浓度与药物治疗频率（“无或很少用药（NSM）”组或“持续用药（CM）”组）之间存在显著相关性。这些结果表明，CRP对皮质类固醇治疗的初始反应可能是犬IPA的预后因素。
To investigate the clinical utility of C-reactive protein (CRP) in idiopathic polyarthritis (IPA), its concentration was measured in dogs with IPA. The CRP concentration was markedly increased in all the IPA dogs at the time of diagnosis and decreased significantly in response to the initial corticosteroid treatment; this indicated that CRP can be used as an index for therapeutic response in IPA cases. Furthermore, at 6 months after the diagnosis, a significant association was observed between the CRP concentration at follow-up (6-13 days after the treatment was started) and the frequency of medication ("no or seldom-medicated (NSM)" groups or "continuing medication (CM)" groups). These results suggest that the initial response of CRP to corticosteroid treatment may be a prognostic factor of canine IPA.