Genetic alterations in pulmonary epithelioid hemangioendothelioma and epithelioid angiosarcoma
Genetic alterations in pulmonary epithelioid hemangioendothelioma and epithelioid angiosarcoma
复制标题
肺上皮样血管内皮瘤和上皮样血管肉瘤的遗传改变
DOI：
10.14670/hh-26.491
复制
发表时间：
2011-04-01
影响因子：
2
通讯作者：
Lin, D. -M.
中科院分区：
文献类型：
--
作者：
Cao, Y.;Zou, S. -M.;Lin, D. -M.
上皮样血管内皮瘤（EHE）是一种发生在许多器官的低至中等级别的血管肿瘤，上皮样血管肉瘤（EA）是与高度恶性相关的血管肉瘤亚型。这两种类型的肿瘤具有不同形式的生物学行为。肺上皮样血管内皮瘤（PEH）和上皮样血管肉瘤（PEA）都是非常罕见的，其遗传学研究非常有限。我们应用阵列-比较基因组杂交（Array-Comparative Genomic Hybridization，Array-CGH）技术对两例肺肿瘤的细胞遗传学特征进行了检测和比较，发现两种肿瘤的细胞遗传学特征存在显著差异。小片段增加（< 10 MB）在PEH中占优势，而大片段增加和缺失（> 10 MB）在PEA中占优势。PEH和PEA的大片段改变，如19 q和19 p的增加和9 p和13 q的缺失，涉及染色体臂的一半以上，细胞遗传学差异很大，因此需要对这两种肿瘤进行进一步的遗传学研究。
Epithelioid hemangioendothelioma (EHE) is a low-to-intermediate-grade vascular tumor that occurs in many organs, and epithelioid angiosarcoma (EA) is a subtype of angiosarcoma that is associated with high-grade malignancy. These two types of tumors have different forms of biological behavior. Pulmonary epithelioid hemangioendothelioma (PEH) and epithelioid angiosarcoma (PEA) are both very rare, and genetic studies on them are extremely limited. We examined and compared the cytogenetic characteristics of these two types of lung tumors in two patients utilizing the Array-Comparative Genomic Hybridization (Array-CGH) method.Considerable differences in the cytogenetic characteristics were observed between the two types of tumors. Small fragment gains (< 10 MB) were dominant in PEH, whereas large fragment gains and deletions (> 10 MB) were dominant in PEA. Some large fragment alterations, such as gains in chromosomes 19q and 19p, and deletions in chromosomes 9p and 13q, involved over half of a chromosome arm.PEH and PEA showed great cytogenetic differences; therefore, further genetic studies on these two types of tumors are warranted.