Influenza encephalopathy associated with infection with human herpesvirus 6 and/or human herpesvirus 7
Influenza encephalopathy associated with infection with human herpesvirus 6 and/or human herpesvirus 7
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DOI：
10.1086/338468
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发表时间：
2002-02-15
影响因子：
11.8
通讯作者：
Asano, Y
中科院分区：
文献类型：
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作者：
Sugaya, N;Yoshikawa, T;Asano, Y
流行性感冒相关脑病常见于日本儿童，但其发病机制尚不清楚。虽然脑病患者的咽喉培养可以证明流感病毒，但脑脊液(CSF)样本的培养不能产生病毒。8例脑病或合并热性惊厥患者，通过培养、聚合酶链式反应(PCR)或咽拭子快速诊断，确诊为流感病毒感染。8例脑脊液标本的流感病毒聚合酶链式反应均为阴性。2例脑脊液标本中检出人类疱疹病毒6(HHV-6)DNA。在8例患者中，有3例在脑脊液标本中发现人类疱疹病毒7型(HHV-7)DNA。日本报告的一些流感相关脑病病例可能与流感病毒和HHV-6、HHV-7或两者同时感染有关。另一种可能性是，流感重新激活了大脑中潜伏的HHV-6或HHV-7，导致脑病或发热性抽搐。
Influenza-associated encephalopathy is often reported in young Japanese children, but its pathogenesis is unknown. Although influenza virus can be demonstrated by throat culture for patients with encephalopathy, cultures of samples of cerebrospinal fluids (CSF) do not yield the virus. Eight patients with encephalopathy or complicated febrile convulsions had influenza virus infection diagnosed by means of culture, polymerase chain reaction (PCR), or rapid diagnosis using throat swabs. In all 8 cases, the results of PCR testing of CSF specimens for influenza virus were negative. On the other hand, human herpesvirus 6 (HHV-6) DNA was demonstrated in CSF specimens obtained from 2 of 8 patients. In 3 of 8 patients, the presence of human herpesvirus 7 (HHV-7) DNA was demonstrated in CSF specimens. Some cases of influenza-associated encephalopathy reported in Japan may be attributable to a dual infection with influenza virus and HHV-6, -7, or both. Another possibility is that latent HHV-6 or HHV-7 in the brain is reactivated by influenza, causing encephalopathy or febrile convulsions.