Imidazopyridine/pyrrole and hydroxybenzimidazole/pyrrole pairs for DNA minor groove recognition
Imidazopyridine/pyrrole and hydroxybenzimidazole/pyrrole pairs for DNA minor groove recognition
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DOI：
10.1021/ja0300158
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发表时间：
2003-05-14
影响因子：
15
通讯作者：
Dervan, PB
中科院分区：
文献类型：
--
作者：
Renneberg, D;Dervan, PB
本文报道了咪唑并[4，5-B]吡啶（1 p）和羟基苯并咪唑（Hz）与吡咯（Py）组成的八环发夹结构的杂环化合物与DNA的结合性质。将Ip/Py和Hz/Py对的识别谱与DNA限制性片段上的五元环对Im/Py和Hp/Py在4个6-碱基对识别位点处进行比较，所述识别位点在单个位置5 ′-TGTNTA-3 ′处变化，其中N = G，C，T，A。Ip/Py对将G-C与C-G、T-A和A-T区分开，Hz/Py对将T-A与A-T、G-C和C-G区分开，提供了一组新的杂环对，以靶向DNA小沟中的四个沃森-克里克碱基对。
The DNA binding properties of fused heterocycles imidazo[4,5-b]pyridine (1p) and hydroxybenzimidazole (Hz) paired with pyrrole (Py) in eight-ring hairpin polyamides are reported. The recognition profile of Ip/Py and Hz/Py pairs were compared to the five-membered ring pairs Im/Py and Hp/Py on a DNA restriction fragment at four 6-base pair recognition sites which vary at a single position 5'-TGTNTA-3', where N = G, C, T, A. The Ip/Py pair distinguishes G-C from C-G, T-A, and A-T, and the Hz/Py pair distinguishes T-A from A-T, G-C, and C-G, affording a new set of heterocycle pairs to target the four Watson-Crick base pairs in the minor groove of DNA.