The embodiment of emotional feelings in the brain.
The embodiment of emotional feelings in the brain.
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DOI：
10.1523/jneurosci.1725-10.2010
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发表时间：
2010-09-22
期刊：
影响因子：
--
通讯作者：
Critchley HD
中科院分区：
文献类型：
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作者：
Harrison NA;Gray MA;Gianaros PJ;Critchley HD
沃尔特·坎农对情绪的外围理论提出的挑战的核心是，身体的唤醒反应太过单一，无法解释丰富的情绪感受。尽管有大量相反的证据，但这一观点仍然被广泛接受，而且近世纪来，内脏传入信号是否对情绪体验至关重要的问题一直没有得到解决。在这里，我们结合联合收割机功能磁共振成像和多器官生理记录，解剖经验的两个不同的厌恶形式和它们的关系，外周和中枢的生理活动。我们发现，核心和身体边界侵犯厌恶的经验是可分离的，在周边自主神经和中枢神经反应，并进一步的情绪体验特定的前岛活动编码这些不同的潜在模式的周边生理反应。这些研究结果表明，器官特异性的生理反应区分情绪的感觉状态，并支持这一假设，即中央代表生物体的生理稳态构成了一个重要方面的神经基础的感情。
Central to Walter Cannon’s challenge to peripheral theories of emotion was that bodily arousal responses are too undifferentiated to account for the wealth of emotional feelings. Despite considerable evidence to the contrary, this remains widely accepted, and for nearly a century has left the issue of whether visceral afferent signals are essential for emotional experience unresolved. Here we combine fMRI and multi-organ physiological recording to dissect experience of two distinct disgust forms and their relation to peripheral and central physiological activity. We show that experience of core and body-boundary-violation disgust are dissociable in both peripheral autonomic and central neural responses and further that emotional experience specific anterior insular activity encodes these different underlying patterns of peripheral physiological responses. These findings demonstrate that organ-specific physiological responses differentiate emotional feeling states and support the hypothesis that central representations of organism physiological homeostasis constitute a critical aspect of the neural basis of feelings.