MOLECULAR ANALYSIS OF THE LOCUS ELAV IN DROSOPHILA-MELANOGASTER - A GENE WHOSE EMBRYONIC EXPRESSION IS NEURAL SPECIFIC
MOLECULAR ANALYSIS OF THE LOCUS ELAV IN DROSOPHILA-MELANOGASTER - A GENE WHOSE EMBRYONIC EXPRESSION IS NEURAL SPECIFIC
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DOI：
10.1002/j.1460-2075.1987.tb04772.x
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发表时间：
1987-02-01
期刊：
影响因子：
11.4
通讯作者：
WHITE, K
中科院分区：
文献类型：
--
作者：
CAMPOS, AR;ROSEN, DR;WHITE, K
果蝇胚胎致死异常视觉系统（elav）基因座是定位于X染色体1B 5 - 1B 9区域的一个重要基因。以前的发展分析表明，除了胚胎的要求，有一个胚胎后的视觉系统细胞的elav功能的要求。通过生殖系转化实验确定了一个含有elav+功能的DNA片段。该区域编码三个胚胎poly（A）+RNA和两个成人转录本，它们优先在头部表达。原位杂交实验清楚地表明elav的胚胎表达仅限于神经系统。
The embryonic lethal abnormal visual system (elav) locus in Drosophila melanogaster, a vital gene mapping within the 1B5-1B9 region of the X-chromosome has been cloned and analysed. Previous development analyses have shown that in addition to the embryonic requirement there is a post-embryonic requirement for elav function in the cells of the visual system. A DNA segment containing elav+ function was defined through germ line transformation experiments. This region encodes three embryonic poly(A)+ RNAs and two adult transcripts which are preferentially expressed in the head. In situ hybridization experiments clearly demonstrate that the embryonic expression of elav is restricted to the nervous system.