Total Syntheses of (-)-Scabronines G and A, and (-)-Episcabronine A
Total Syntheses of (-)-Scabronines G and A, and (-)-Episcabronine A
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DOI：
10.1002/anie.201303224
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发表时间：
2013-07-15
影响因子：
16.6
通讯作者：
Nakada, Masahisa
中科院分区：
文献类型：
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作者：
Kobayakawa, Yu;Nakada, Masahisa
（E）-ScabroninesA-G（图1）和（E）-episcabronine A（2）是从苦蘑菇Sarcodon scabrosus中分离出来的，Ohta等人对其进行了表征。[1](Scabronine A（1）在其七元环中含有六个连续的立体中心，因此将其区分为Scabronine家族中最复杂的结构。（N）-Scabronine G（3）具有已知Scabronines中氧化程度最低的七元环，其氧化态范围在1和3之间。通过各种氧化过程从3的生物遗传偏差推断的隔离的天然产物的阵列。
(À)-ScabroninesA–G (Figure1) and (À)-episcabronine A (2) were isolated from the bitter mushroom, Sarcodon scabrosus, and characterized by Ohta et al.[1](À)-Scabronine A (1) contains six contiguous stereogenic centers in its seven-membered ring, thus distinguishing it as the most complex structure in the scabronine family.(À)-Scabronine G (3) possesses the least oxidized seven-membered ring of known scabronines, which range in oxidation state between 1 and 3. Biogenetic deviation of 1 from 3 through various oxidation processes is inferred by the array of isolated natural products.