The boundary shift integral: An accurate and robust measure of cerebral volume changes from registered repeat MRI
The boundary shift integral: An accurate and robust measure of cerebral volume changes from registered repeat MRI
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DOI：
10.1109/42.640753
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发表时间：
1997-10-01
影响因子：
10.6
通讯作者：
Fox, NC
中科院分区：
文献类型：
--
作者：
Freeborough, PA;Fox, NC
我们提出边界移位积分（BSI）作为从配准的重复三维（3-D）磁共振（MR）[3D MR]扫描导出的脑体积变化的量度。BSI直接从体素强度确定给定脑结构的边界已经移动通过的总体积，并且因此确定体积变化，我们发现大脑和心室的BSI密切相关（r = 1.000和r = 0.999），具有模拟的变化量，应用于21个对照扫描对和11个来自阿尔茨海默病（AD）患者的扫描对（平均间隔386天）BSI产生的平均脑容量损失为1.8 cc AD组为34.7cc;对照组则紧紧地捆在一起（SD = 3.8 cc），并且存在广泛的组分离，组平均值相差8.7个对照组标准偏差（SD），基于BSI使用的相同分割的测量产生了相似的组平均值，但在对照组中分布广泛（SD = 13.4 cc）和组重叠，组平均值相差2.8个对照组SD，BSI得出的平均心室容积损失为0.4 cc（对照组）和10.1 cc（AD），线性相关性良好（r = 0.997），我们的结论是BSI是一个准确和强大的测量区域和全球脑容量的变化。
We propose the boundary shift integral (BSI) as a measure of cerebral volume changes derived from registered repeat three-dimensional (3-D) magnetic resonance (MR) [3D MR] scans, The BSI determines the total volume through which the boundaries of a given cerebral structure have moved and, hence, the volume change, directly from voxel intensities, We found brain and ventricular BSI's correlated tightly (r = 1.000 and r = 0.999) with simulated volumes of change, Applied to 21 control scan pairs and 11 scan pairs from Alzheimer's disease (AD) patients (mean interval 386 days) the BSI yielded mean brain volume loss of 1.8 cc (controls) and 34.7 cc (AD); the control group was tightly bunched (SD = 3.8 cc) and there was wide group separation, the group means differing by 8.7 control group satndard deviations (SD's), A measure based on the same segmentation used by the BSI yielded similar group means, but wide spread in the control group (SD = 13.4 cc) and group overlap, the group means differing by 2.8 control group SD's, The BSI yielded mean ventricular volume losses of 0.4 cc (controls) and 10.1 cc (AD), Good linear correlation (r = 0.997) was obtained between the ventricular BSI and the difference in their segmented volumes, We conclude the BSI is an accurate and robust measure of regional and global cerebral volume changes.