ANALYSIS OF [H-3] SPIPERONE BINDING-SITES IN THE RAT STRIATUM AND FRONTOPARIETAL CORTEX BY MEANS OF QUANTITATIVE RECEPTOR AUTORADIOGRAPHY AFTER INACTIVATION OF DOPAMINE-RECEPTORS BY N-ETHOXYCARBONYL-2-ETHOXY-1,2-DIHYDROQUINOLINE INVIVO - SELECTIVE PROTECTION BY SULPIRIDE IN THE STRIATUM
ANALYSIS OF [H-3] SPIPERONE BINDING-SITES IN THE RAT STRIATUM AND FRONTOPARIETAL CORTEX BY MEANS OF QUANTITATIVE RECEPTOR AUTORADIOGRAPHY AFTER INACTIVATION OF DOPAMINE-RECEPTORS BY N-ETHOXYCARBONYL-2-ETHOXY-1,2-DIHYDROQUINOLINE INVIVO - SELECTIVE PROTECTION BY SULPIRIDE IN THE STRIATUM
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DOI：
10.1016/0304-3940(86)90093-5
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发表时间：
1986-02-28
影响因子：
2.5
通讯作者：
AGNATI, LF
中科院分区：
文献类型：
--
作者：
FUXE, K;MELLER, E;AGNATI, LF
By means of quantitative receptor autoradiography in combination with inactivation of dopamine (DA) receptors by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ), it was demonstrated in the male rat that [3H]spiperone predominantly labels D2 receptors in the striatum, nucleus accumbens and tuberculum olfactorium and predominantly non-DA receptors in the frontoparietal cortex, probably mainly serotonin type 2 (5-HT2) receptors in layer IV. Furthermore, the [3H]spiperone-labelled D2 receptors found all over the dorsal and ventral striatum appear to be similarly inactivated by EEDQ and protected by the D2 antagonist (.+-.)-sulpiride but not the D1 antagonist SCH 23390, indicating a homogeneity of the striatal D2 receptors.
