Advances in the Development Ubiquitin-Specific Peptidase (USP) Inhibitors.
Advances in the Development Ubiquitin-Specific Peptidase (USP) Inhibitors.
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泛素特异性肽酶抑制剂的研究进展。
DOI：
10.3390/ijms22094546
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发表时间：
2021-04-27
影响因子：
5.6
通讯作者：
Zhou H
中科院分区：
文献类型：
--
作者：
Chen S;Liu Y;Zhou H
泛素化和去泛素化是在生理条件下蛋白质降解的调节的翻译后修饰（PTM）过程。分子信号的种类在过去的十年中，包括DNA损伤修复，p53和转化生长因子-β（TGF-β）途径。
Ubiquitylation and deubiquitylation are reversible protein post-translational modification (PTM) processes involving the regulation of protein degradation under physiological conditions. Loss of balance in this regulatory system can lead to a wide range of diseases, such as cancer and inflammation. As the main members of the deubiquitinases (DUBs) family, ubiquitin-specific peptidases (USPs) are closely related to biological processes through a variety of molecular signaling pathways, including DNA damage repair, p53 and transforming growth factor-β (TGF-β) pathways. Over the past decade, increasing attention has been drawn to USPs as potential targets for the development of therapeutics across diverse therapeutic areas. In this review, we summarize the crucial roles of USPs in different signaling pathways and focus on advances in the development of USP inhibitors, as well as the methods of screening and identifying USP inhibitors.
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影响因子：
6.4
作者：
Berndtsson, Maria;Beaujouin, Melanie;Linder, Stig
通讯作者：
Linder, Stig
影响因子：
3.4
作者：
Colombo, Matteo;Vallese, Stefania;Guedat, Philippe
通讯作者：
Guedat, Philippe
影响因子：
5.7
作者：
Colland, Frederic;Formstecher, Etienne;Daviet, Laurent
通讯作者：
Daviet, Laurent
影响因子：
56.9
作者：
CHAU, V;TOBIAS, JW;VARSHAVSKY, A
通讯作者：
VARSHAVSKY, A
影响因子：
4.8
作者：
Berlin, Ilana;Higginbotham, Katherine M.;Nash, Piers D.
通讯作者：
Nash, Piers D.