The effect of exogenous angiotensin on superficial and deep glomeruli in the rat kidney.
The effect of exogenous angiotensin on superficial and deep glomeruli in the rat kidney.
复制标题
外源性血管紧张素对大鼠肾脏浅层和深层肾小球的影响。
DOI：
10.1038/ki.1972.117
复制
发表时间：
1972
影响因子：
19.6
通讯作者：
G. Richet
中科院分区：
文献类型：
--
作者：
H. Hornych;M. Beaufils;G. Richet
外源性血管紧张素对大鼠浅、深肾小球的影响。用扫描电子显微镜观察外源性血管紧张素对肾小球毛细血管的影响。这项技术非常适合，因为它以三维显示肾小球小球，这要归功于它相当大的景深，以及它的大范围放大和良好的分辨率(150A)。体内固定方法允许保存可能发生的任何形态变化。血管紧张素通过外周静脉注射30或60分钟，可引起肾小球表面毛细血管的收缩和上皮细胞的明显变化。这些变化在非加压剂量的激素后已经很明显，并且与注射剂量成正比。相反，除了体积显著增加外，延髓旁肾小球的形态没有变化。这些由血管紧张素引起的变化被认为是特定的，因为它们被抗血管紧张素血浆完全阻断，而且用阿尔法阻滞剂酚妥拉明(Regitin®)预处理未能阻止它们。它们在24小时内完全可逆。这一结果与血管紧张素对肾小球毛细血管的影响在形态上是一致的，并且与肾皮质血流的重新分布是一致的。
The effect of exogenous angiotensin on superficial and deep glomeruli in the rat. The effect of exogenous angiotensin on the glomerular capillaries was studied with the help of the scanning electron microscope. This technique is well suited because it shows the glomerular floculus in three dimensions thanks to its considerable depth of field and its great range of enlargement and good resolution (150 A). The in vivo method of fixation allows the preservation of any morphological changes which may occur. Angiotensin administered via a peripheral vein for 30 or 60 minutes produced vasoconstriction of the glomerular capillaries in the superficial glomeruli and distinct changes in the epithelial cells. These changes were already apparent after nonpressor doses of the hormone and were proportional to the injected dose. On the contrary, no changes were noted in the morphology of the juxtamedullary glomeruli, with the exception that a significant increase was noted in their volume. These changes brought about by the administration of angiotensin are thought to be specific because they were completely blocked by anti-angiotensin plasma and because pretreatment with the alpha blocker, phentolamine (Regitin®), failed to prevent them. They were completely reversible in 24 hours. The results give the morphological counterpart of the influence of angiotensin on the glomerular capillaries and are in keeping with a redistribution of the cortical renal blood flow.