Hyperoxaluria-induced oxidative stress and antioxidants for renal protection
Hyperoxaluria-induced oxidative stress and antioxidants for renal protection
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DOI：
10.1007/s00240-005-0492-4
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发表时间：
2005-11-01
影响因子：
--
通讯作者：
Khan, SR
中科院分区：
文献类型：
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作者：
Khan, SR
肾细胞暴露于草酸盐（Ox）和/或CaOx晶体导致活性氧（ROS）的产生，氧化应激的发展，随后是损伤和炎症。肾损伤和炎症似乎在结石形成中起重要作用。ROS的产生有多种来源，涉及多种信号通路。组织培养和动物模型研究表明，抗氧化剂和自由基清除剂的治疗减少了Ox/CaOx晶体诱导的损伤。此外，通过用抗氧化剂和自由基清除剂治疗，肾脏中的CaOx晶体沉积显著减少，表明它们的功效。这些结果指出了抗氧化剂和自由基清除剂的治疗应用的巨大潜力，以减少结石复发，特别是在冲击波碎石术后，这本身是已知的产生ROS和引起肾损伤。
Renal cellular exposure to oxalate (Ox) and/or CaOx crystals leads to the production of reactive oxygen species (ROS), development of oxidative stress followed by injury and inflammation. Renal injury and inflammation appear to play a significant role in stone formation. ROS are produced from many sources and involve a variety of signaling pathways. Tissue culture and animal model studies show that treatments with anti-oxidants and free radical scavengers reduce Ox/CaOx crystal induced injuries. In addition, CaOx crystal deposition in kidneys is significantly reduced by treatments with antioxidants and free radical scavengers, indicating their efficacy. These results point towards a great potential for the therapeutic application of antioxidants and free radical scavengers to reduce stone recurrence particularly after shock wave lithotripsy, which is itself known to generate ROS and cause renal damage.