Stem cell pluripotency: a cellular trait that depends on transcription factors, chromatin state and a checkpoint deficient cell cycle.
Stem cell pluripotency: a cellular trait that depends on transcription factors, chromatin state and a checkpoint deficient cell cycle.
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DOI：
10.1002/jcp.21866
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发表时间：
2009-10
影响因子：
5.6
通讯作者：
Boheler, Kenneth R.
中科院分区：
文献类型：
--
作者：
Boheler, Kenneth R.
胚胎干细胞（ES）和诱导多能干细胞（iPS）具有自我更新和多能性。这些细胞的分化可以产生200多种体细胞类型，使多能细胞成为再生医学的明显来源。在最大限度地利用这些细胞的潜力用于临床应用之前，有必要了解维持多能性和信号分化的过程。目前，有三个独特的分子特性将多能干细胞与体细胞区分开来。这包括在自我更新过程中维持多能状态的独特转录层次结构；一种平衡的表观遗传状态，使染色质处于一种为细胞命运的快速决定做好准备的状态；细胞周期以极短的间隙1 （G1）期和几乎没有正常的体细胞检查点控制为特征。最近，B-MYB （MYBL2）参与了两种多能因子和正常细胞周期进程的基因调控。本文将讨论B-Myb的三种多能性及其调控这些过程的潜在作用。
Embryonic stem (ES) and induced pluripotent stem (iPS) cells self-renew and are pluripotent. Differentiation of these cells can yield over 200 somatic cell types, making pluripotent cells an obvious source for regenerative medicine. Before the potential of these cells can be maximally harnessed for clinical applications, it will be necessary to understand the processes that maintain pluripotentiality and signal differentiation. Currently, three unique molecular properties distinguish pluripotent stem cells from somatic cells. These include a unique transcriptional hierarchy that sustains the pluripotent state during the process of self-renewal; a poised epigenetic state that maintains chromatin in a form ready for rapid cell fate decisions; and a cell cycle characterized by an extremely short gap 1 (G1) phase and the near absence of normal somatic cell checkpoint controls. Recently, B-MYB (MYBL2) was implicated in the gene regulation of two pluripotency factors and normal cell cycle progression. In this article, the three pluripotency properties and the potential role of B-Myb to regulate these processes will be discussed.
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