AN INDEX OF THE FUNCTIONAL-CONDITION OF RAT SCIATIC-NERVE BASED ON MEASUREMENTS MADE FROM WALKING TRACKS
AN INDEX OF THE FUNCTIONAL-CONDITION OF RAT SCIATIC-NERVE BASED ON MEASUREMENTS MADE FROM WALKING TRACKS
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DOI：
10.1016/0014-4886(82)90234-5
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发表时间：
1982-01-01
影响因子：
5.3
通讯作者：
WYATT, RJ
中科院分区：
文献类型：
--
作者：
DEMEDINACELI, L;FREED, WJ;WYATT, RJ
目前还没有广泛接受的定量方法来评估动物周围神经损伤对功能的影响。在本研究中，评价坐骨神经损伤的方法，从测量的足迹的后足的步行大鼠保存在X线片。从这些轨迹中测量四个变量，并将受损（实验）和完好（正常）侧之间的比较转换为缺陷百分比，并取平均值以获得“坐骨神经功能指数”（SFI）。然后在正常条件下，神经横断，神经挤压和假手术后测量SFI。SFI的可靠性和可重复性被认为是优秀的。用该方法评价坐骨神经横断和夹伤的效果与其他评价神经损伤的方法一致。结论：SFI为评价大鼠坐骨神经功能状况提供了一种简便、准确、可靠、重复性好的方法。
There is no widely accepted quantitative method for evaluating the functional effects of peripheral nerve damage in animals. In the present study, a method for evaluating sciatic nerve damage was developed from measurements of the prints of the hind feet of walking rats preserved on X-ray film. Four variables were measured from these tracks, and comparisons between the damaged (experimental) and intact (normal) side were converted to percent deficits and averaged to obtain a “sciatic functional index” (SFI). The SFI was then measured under normal conditions, after nerve transection, nerve crush, and sham procedures. Reliability and repeatability of the SFI were found to be excellent. The effects of sciatic nerve transection and nerve crush evaluated by this method agreed very well with other methods of evaluating nerve damage. We conclude that the SFI provides a simple, accurate, reliable, and repeatable method for evaluating the functional condition of sciatic nerve in rats.