Regenerative medicine as applied to general surgery.
Regenerative medicine as applied to general surgery.
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再生医学应用于普通外科。
DOI：
10.1097/sla.0b013e318243a4db
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发表时间：
2012-05
影响因子：
9
通讯作者：
Soker S
中科院分区：
文献类型：
--
作者：
Orlando G;Wood KJ;De Coppi P;Baptista PM;Binder KW;Bitar KN;Breuer C;Burnett L;Christ G;Farney A;Figliuzzi M;Holmes JH 4th;Koch K;Macchiarini P;Mirmalek Sani SH;Opara E;Remuzzi A;Rogers J;Saul JM;Seliktar D;Shapira-Schweitzer K;Smith T;Solomon D;Van Dyke M;Yoo JJ;Zhang Y;Atala A;Stratta RJ;Soker S
本综述说明了应用于外科疾病的再生医学（RM）的最新技术水平，并表明该领域有潜力解决外科手术中一些未满足的需求。RM是一个多学科领域，其目的是通过开发人体细胞、组织和器官固有的再生潜力，在体内或离体再生人体细胞、组织或器官，以恢复或建立正常功能。RM使用细胞和/或专门设计的生物材料来实现其目标，基于RM的疗法已经在大多数外科领域的几项临床试验中使用。研究人员面临的主要挑战有三个方面：创造一个适当的离体微环境，能够维持细胞生理学和功能，以产生所需的细胞或身体部位;识别和适当操作有潜力在体内和离体产生实质，基质和血管成分的细胞;以及生产能够驱动细胞命运的智能材料。
The present review illustrates the state of the art of regenerative medicine (RM) as applied to surgical diseases and demonstrates that this field has the potential to address some of the unmet needs in surgery. RM is a multidisciplinary field whose purpose is to regenerate in vivo or ex vivo human cells, tissues or organs in order to restore or establish normal function through exploitation of the potential to regenerate, which is intrinsic to human cells, tissues and organs. RM uses cells and/or specially designed biomaterials to reach its goals and RM-based therapies are already in use in several clinical trials in most fields of surgery. The main challenges for investigators are threefold: Creation of an appropriate microenvironment ex vivo that is able to sustain cell physiology and function in order to generate the desired cells or body parts; identification and appropriate manipulation of cells that have the potential to generate parenchymal, stromal and vascular components on demand, both in vivo and ex vivo; and production of smart materials that are able to drive cell fate.