Dental radiography after age 25 years, amalgam fillings and tumours of the central nervous system
Dental radiography after age 25 years, amalgam fillings and tumours of the central nervous system
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DOI：
10.1016/s1368-8375(98)80006-7
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发表时间：
1998-07-01
期刊：
影响因子：
4.8
通讯作者：
Sp채nnare, B
中科院分区：
文献类型：
--
作者：
Rodvall, Y;Ahlbom, A;Sp채nnare, B
这项研究的目的是调查诊断牙科X光检查和银汞合金填充作为中枢神经系统(CNS)谣言的危险因素的重要性。这项以人群为基础的病例对照研究包括了居住在瑞典乌普萨拉大学医院神经外科的年龄在25-74岁之间的受试者。1987~1990年共确诊脑胶质瘤192例，脑膜瘤99例，听神经瘤42例。一组343名受试者在年龄、性别和教区方面进行了匹配。有关牙齿暴露的信息是通过自填式问卷和牙齿记录获得的。对于那些在25岁后每年至少做一次牙科X光检查的人来说，脑膜瘤的相对风险为2.1(95%可信区间为1.0-4.3)，而对于中枢神经系统肿瘤的其他亚组来说，相对风险接近于1。未观察到银汞合金填充物的数量与中枢神经系统肿瘤之间的关系。总之，没有明确的证据表明牙科摄影或银汞合金填充物与中枢神经系统肿瘤的发展有关。(C)1998爱思唯尔科学有限公司。保留所有权利。
The aim of the study was to investigate the importance of diagnostic dental radiography and amalgam fillings as risk factors for rumours of the central nervous system (CNS). This population-based case-control study included subjects aged 25-74 years, living in the catchment area of the Neurosurgery Department of Uppsala University Hospital in Sweden. A total of 192 cases of glioma, 99 cases of meningioma and 42 cases of acoustic neurinoma were identified between 1987 and 1990. A control group of 343 subjects was matched on age, gender and parish. Information about dental exposure was obtained by a self-administered questionnaire and from dental records. For those who had a dental radiography at least once a year after age 25 years, a relative risk of 2.1 (95% confidence interval (CI) 1.0-4.3) was seen for meningioma, while for other subgroups of CNS tumours the relative risk was close to unity. No association was observed between the number of amalgam fillings and CNS tumours. In conclusion, there was no clear evidence that dental radiography or amalgam fillings is related to the development of tumours of the CNS. (C) 1998 Elsevier Science Ltd. All rights reserved.