Glycyrrhetinic Acid Functionalized Nanoparticles for Drug Delivery to Liver Cancer. J Biomed Nanotechnol
Glycyrrhetinic Acid Functionalized Nanoparticles for Drug Delivery to Liver Cancer. J Biomed Nanotechnol
复制标题
用于肝癌药物输送的甘草次酸功能化纳米颗粒。
DOI：
10.1166/jbn.2018.2638
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Gao Z
中科院分区：
文献类型：
--
作者：
Wu F;Li X;Jiang B;Yan J;Zhang Z;Qin J;Yu W;Gao Z
肝癌是世界范围内最常见的人类恶性肿瘤之一。目前，化疗仍然是肝癌治疗的基石。但化疗常引起许多副作用，如白细胞减少、消化道反应、肝肾功能障碍和脱发等。最近，基于纳米颗粒的肝靶向药物递送系统取得了巨大进展，以克服这些问题。甘草次酸（GA）是从甘草中提取的一种五环三萜类化合物，广泛用于肝癌的治疗。GA能够通过肝实质细胞表面的GA-R的特异性位点与肝细胞结合。从这一前景，这一审查重点GA介导的纳米粒肝靶向药物输送系统从不同的聚合物材料。
Liver cancer is one of the most common human malignancies worldwide. Currently, chemotherapy remains the cornerstone for liver cancer treatment. However, chemotherapy often causes many side effects, such as leukopenia, digestive reaction, hepatic and renal dysfunction and hair loss. Recently, great advances in nanoparticles-based liver-targeting drug delivery systems have been developed to overcome these problems. Glycyrrhetinic acid (GA), a pentacyclic triterpenoid extracted from the root of licorice, and has been widely used in liver cancer therapy. GA is capable of binding to hepatocytes via the specific site of GA-R on the surface of hepatic parenchymatous cells. From this prospective, this review highlights GA-mediated nanoparticles liver-targeting drug delivery systems from different polymer materials.