Development and implementation of a pharmacist-managed clinical pharmacogenetics service
Development and implementation of a pharmacist-managed clinical pharmacogenetics service
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DOI：
10.2146/ajhp100113
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发表时间：
2011-01-15
影响因子：
2.7
通讯作者：
Hoffman, James M.
中科院分区：
文献类型：
--
作者：
Crews, Kristine R.;Cross, Shane J.;Hoffman, James M.
目的.描述了药师管理的临床药物遗传学服务的开发和实施。一个药剂师管理的临床药物遗传学服务的设计和实施，在一个学术专业医院提供临床药物遗传学检测的基因产品，重要的药物在医院的病人的药效学。为我们的药剂师举办了一系列经认证的教育研讨会，以建立为临床药物遗传学服务检测的基因提供药物遗传学咨询的能力。该服务是仿照并整合了一个已经建立的临床药代动力学服务。成立了一个指导委员会，以评估现有测试的使用情况、实施额外测试的新证据以及其他服务质量指标。所有临床药物遗传学试验结果首先报告给其中一名药剂师，由其审查结果并提供书面咨询。咨询包括对结果的解释和对任何治疗变化的建议。2009年，进行了136项临床药物遗传学试验。该服务得到了临床医生的积极反馈。这项服务的成功实施突出了药剂师在将药物遗传学从研究转移到患者护理方面的领导作用。发展和经验与药师管理的临床药物遗传学服务的描述。该计划的成功依赖于临床实验室和药剂师之间的合作，药剂师的药物遗传学建议已被广泛接受。开处方者。
Purpose. The development and implementation of a pharmacist-managed clinical pharmacogenetics service are described.Summary. A pharmacist-managed clinical pharmacogenetics service was designed and implemented at an academic specialty hospital to provide clinical pharmacogenetic testing for gene products important to the pharmacodynamics of medications used in the hospital's patients. A series of accredited educational seminars were conducted for our pharmacists to establish competencies in providing pharmacogenetic consults for the genes to be tested by the clinical pharmacogenetics service. The service was modeled after and integrated with an already-established clinical pharmacokinetics service. A steering committee was formed to evaluate the use of available tests, new evidence for implementation of additional tests, and other service quality metrics. All clinical pharmacogenetic test results are first reported to one of the pharmacists, who reviews the result and provides a written consultation. The consultation includes an interpretation of the result and recommendations for any indicated changes to therapy. In 2009, 136 clinical pharmacogenetic tests were performed. The service has been met with positive clinician feedback. The successful implementation of this service highlights the leadership role that pharmacists can take in moving pharmacogenetics from research to patient care.Conclusion. The development of and experience with a pharmacist-managed clinical pharmacogenetics service are described. The program's success has depended on collaboration between the clinical laboratory and pharmacists, and pharmacists' pharmacogenetic recommendations have been well accepted by. prescribers.