Mechanical Properties and Failure of Biopolymers: Atomistic Reactions to Macroscale Response.
Mechanical Properties and Failure of Biopolymers: Atomistic Reactions to Macroscale Response.
复制标题
生物聚合物的机械性能和失效：原子反应到宏观响应。
DOI：
10.1007/128_2015_643
复制
发表时间：
2015
影响因子：
8.6
通讯作者：
Buehler,MarkusJ
中科院分区：
文献类型：
--
作者：
Jung,GangSeob;Qin,Zhao;Buehler,MarkusJ
生物材料在各种机械载荷作用下的化学键行为是一种有趣的力学-化学性质，它对决定生物材料的变形和破坏机制起着至关重要的作用。生物蛋白质材料由于其惊人的力学性能和在构成各种生理相关材料的基础上所起的作用，受到了广泛的研究。了解化学键网络(结构)与其机械性能之间的关系为纳米技术中的新材料设计和人类疾病的新医学治疗提供了巨大的可能性。在这里，我们重点研究生物系统中的化学键如何影响机械性能，以及它们在机械变形和破坏过程中如何变化。在案例研究中讨论了与人类疾病相关的三个具有代表性的生物材料案例，包括：淀粉样蛋白、中间纤维和胶原，每个案例都描述了机械力化学特征以及它们如何在多个尺度上与病理条件相关。
The behavior of chemical bonding under various mechanical loadings is an intriguing mechanochemical property of biological materials, and the property plays a critical role in determining their deformation and failure mechanisms. Because of their astonishing mechanical properties and roles in constituting the basis of a variety of physiologically relevant materials, biological protein materials have been intensively studied. Understanding the relation between chemical bond networks (structures) and their mechanical properties offers great possibilities to enable new materials design in nanotechnology and new medical treatments for human diseases. Here we focus on how the chemical bonds in biological systems affect mechanical properties and how they change during mechanical deformation and failure. Three representative cases of biomaterials related to the human diseases are discussed in case studies, including: amyloids, intermediate filaments, and collagen, each describing mechanochemical features and how they relate to the pathological conditions at multiple scales.