Expression and significance of MMP-9 and MDM2 in the oncogenesis of lung cancer in rats
Expression and significance of MMP-9 and MDM2 in the oncogenesis of lung cancer in rats
复制标题
DOI：
10.1016/s1995-7645(14)60099-7
复制
发表时间：
2014-07-01
影响因子：
3.1
通讯作者：
Zhao, Jin-Zao
中科院分区：
文献类型：
--
作者：
Zhang, De-Hui;Zhang, Liang-Yu;Zhao, Jin-Zao
目的：观察基质金属蛋白酶9（MMP-9）和小鼠双分钟2同源物（MDM2）在大鼠肺癌发生过程中的表达，探讨其临床价值。方法：选取大鼠140只，随机抽取20只作为对照组；其余120人为观察组。观察组注射苯并芘建立组织增殖、异常增殖、肺癌等疾病模型。采用酶联法检测肺组织中MMP-9的含量，采用免疫化学法检测肺组织中MDM2的含量。结果:肺癌组和异常增殖组MMP-9、MDM2的表达量显着高于组织增殖组和对照组,差异有显着性(P
Objective: To observe the expression of matrix metalloproteinase-9 (MMP-9) and mouse double minute 2 homolog (MDM2) in the oncogenesis of lung cancer in rats and to explore their clinical value. Methods: A total of 140 rats were selected, of which 20 were selected randomly as the control group; and the remaining 120 as the observation group. The observation group was injected with benzopyrene to establish diseases model such as tissue proliferation, abnormal proliferation and lung cancer. Detected the MMP-9 levels of lung tissue by enzyme linked assay, detected the MDM2 levels of lung tissue by immunochemistry assay. Results: The MMP-9 and MDM2 expression of the lung cancer group and the abnormal proliferation group were significantly higher than that in the tissue proliferation group and the control group, the difference was significant (P