Comparison of elevated phosphorylated neurofilament heavy chains in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis
Comparison of elevated phosphorylated neurofilament heavy chains in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis
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DOI：
10.1136/jnnp-2017-316605
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发表时间：
2018-04-01
影响因子：
11
通讯作者：
Poesen, Koen
中科院分区：
文献类型：
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作者：
De Schaepdryver, Maxim;Jeromin, Andreas;Poesen, Koen
目的肌萎缩侧索硬化（ALS）患者脑脊液（CSF）中磷酸化神经丝重链（pNfH）水平升高。而不是CSF，我们探讨血液作为替代来源，以衡量pNfH患者ALS.Methods在这个单中心的回顾性研究，85例ALS，215疾病对照（DC）和31 ALS模拟。个体血清pNfH浓度与CSF中的浓度和几个临床参数相关。结果ALS患者脑脊液和血清pNfH浓度相关性良好（r = 0.652，p < 0.01），ALS患者脑脊液和血清pNfH浓度相关性较好（r=0.652，p < 0.01），ALS患者脑脊液和血清pNfH浓度相关性较好（r=0.652，p < 0.01），ALS患者脑脊液和血清pNfH浓度相关性较好（r=0.652，p < 0.01），ALS患者脑脊液和血清pNfH浓度相关性较好（r=0.652，p < 0.01）。
Objective Phosphorylated neurofilament heavy chain (pNfH) levels are elevated in cerebrospinal fluid (CSF) of patients with amyotrophic lateral sclerosis (ALS). Instead of CSF, we explored blood as an alternative source to measure pNfH in patients with ALS.Methods In this single centre retrospective study, 85 patients with ALS, 215 disease controls (DC) and 31 ALS mimics were included. Individual serum pNfH concentrations were correlated with concentrations in CSF and with several clinical parameters. The performance characteristics of pNfH in CSF and serum of patients with ALS and controls were calculated and compared using receiver operating characteristic (ROC) curves.Results CSF and serum pNfH concentrations in patients with ALS correlated well (r=0.652, p