BiP mRNA expression is upregulated by dehydration in vasopressin neurons in the hypothalamus in mice
BiP mRNA expression is upregulated by dehydration in vasopressin neurons in the hypothalamus in mice
复制标题
DOI：
10.1016/j.peptides.2011.12.011
复制
发表时间：
2012-02-01
期刊：
影响因子：
3
通讯作者：
Oiso, Yutaka
中科院分区：
文献类型：
--
作者：
Hagiwara, Daisuke;Arima, Hiroshi;Oiso, Yutaka
免疫球蛋白重链结合蛋白（BiP）是一种内质网（ER）伴侣蛋白，有助于新合成的分泌蛋白和跨膜蛋白的正确折叠。在这里，我们报告，BiP mRNA表达在视上核（SON）和室旁核（PVN）的野生型小鼠在基础条件下的下丘脑。在SON和PVN的双重原位杂交显示，BiP mRNA表达在几乎所有的精氨酸加压素（AVP），一种抗利尿激素的神经元。在脱水条件下，SON和PVN中BiP mRNA表达水平与AVP mRNA表达水平成比例增加。这些数据表明，BiP参与SON和PVN中AVP神经元的ER功能的稳态。(C)2012 Elsevier Inc. All rights reserved.
The immunoglobulin heavy chain binding protein (BiP) is an endoplasmic reticulum (ER) chaperone that facilitates the proper folding of newly synthesized secretory and transmembrane proteins. Here we report that BiP mRNA was expressed in the supraoptic nucleus (SON) and paraventricular nucleus (PVN) of the hypothalamus in wild-type mice under basal conditions. Dual in situ hybridization in the SON and PVN demonstrated that BiP mRNA was expressed in almost all the neurons of arginine vasopressin (AVP), an antidiuretic hormone. BiP mRNA expression levels were increased in proportion to AVP mRNA expression in the SON and PVN under dehydration. These data suggest that BiP is involved in the homeostasis of ER function in the AVP neurons in the SON and PVN. (C) 2012 Elsevier Inc. All rights reserved.