THE LYMPHOCYTE-B ADHESION MOLECULE CD22 INTERACTS WITH LEUKOCYTE COMMON ANTIGEN CD45RO ON T-CELLS AND ALPHA-2-6 SIALYLTRANSFERASE, CD75, ON B-CELLS
THE LYMPHOCYTE-B ADHESION MOLECULE CD22 INTERACTS WITH LEUKOCYTE COMMON ANTIGEN CD45RO ON T-CELLS AND ALPHA-2-6 SIALYLTRANSFERASE, CD75, ON B-CELLS
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DOI：
10.1016/0092-8674(91)90036-x
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发表时间：
1991-09-20
期刊：
影响因子：
64.5
通讯作者：
ANDERSON, T
中科院分区：
文献类型：
--
作者：
STAMENKOVIC, I;SGROI, D;ANDERSON, T
B淋巴细胞的功能成熟与B系特异性细胞表面糖蛋白CD22的表达有关。两个CD22多肽已被鉴定，并被认为在B细胞与B细胞的相互作用以及B细胞与单核细胞的黏附中发挥作用。在这项工作中，我们提供了CD22直接参与B细胞和T细胞之间同源相互作用的证据。CD22多肽中的一种，CD22-β，与CD4+T细胞亚群上的特定配体相互作用。我们的结果提示CD22的T细胞配体是CD45RO，它是与辅助性T细胞表型相关的白细胞共同抗原型磷酸酪氨酸磷酸酶的同种形式。我们进一步证明，CD22识别第二个配体CD75，它主要表达在激活的B细胞上，并被证明是细胞表面的α-2-6唾液酸转移酶。
Functional maturation of B lymphocytes correlates with expression of the B lineage-specific cell surface glycoprotein CD22. Two CD22 polypeptides have been characterized and suggested to play a role in B cell-B cell interaction as well as in B cell adhesion to monocytes. In this work we provide evidence that CD22 is directly involved in the cognate interaction between B and T cells. One of the two CD22 polypeptides, CD22-beta, interacts with a specific ligand on a subpopulation of CD4+ T cells. Our results suggest that the T cell ligand of CD22 is CD45RO, an isoform of the leukocyte common antigen class of phosphotyrosine phosphatases associated with the helper T cell phenotype. We further demonstrate that CD22 recognizes a second ligand, CD75, expressed predominantly on activated B cells and shown to be a cell surface alpha-2-6 sialytransferase.